Povezanost polimorfizama gena za serotoninske 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C I 5-HT6 receptore u oboljelih od shizofrenije i akutnih ekstrapiramidalnih nuspojava antipsihotika haloperidola

Grubor, Mirko

prikaz prve stranice dokumenta Povezanost polimorfizama gena za serotoninske 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C I 5-HT6 receptore u oboljelih od shizofrenije i akutnih ekstrapiramidalnih nuspojava antipsihotika haloperidola

doctoral thesis

Povezanost polimorfizama gena za serotoninske 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C I 5-HT6 receptore u oboljelih od shizofrenije i akutnih ekstrapiramidalnih nuspojava antipsihotika haloperidola

Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. urn:nbn:hr:163:144566

Grubor, Mirko

University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

APA 6th Edition

Grubor, M. (2020). Povezanost polimorfizama gena za serotoninske 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C I 5-HT6 receptore u oboljelih od shizofrenije i akutnih ekstrapiramidalnih nuspojava antipsihotika haloperidola (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:144566

MLA 8th Edition

Grubor, Mirko. "Povezanost polimorfizama gena za serotoninske 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C I 5-HT6 receptore u oboljelih od shizofrenije i akutnih ekstrapiramidalnih nuspojava antipsihotika haloperidola." Doctoral thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. https://urn.nsk.hr/urn:nbn:hr:163:144566

Chicago 17th Edition

Harvard

Grubor, M. (2020). 'Povezanost polimorfizama gena za serotoninske 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C I 5-HT6 receptore u oboljelih od shizofrenije i akutnih ekstrapiramidalnih nuspojava antipsihotika haloperidola', Doctoral thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 09 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:144566

Vancouver

Grubor M. Povezanost polimorfizama gena za serotoninske 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C I 5-HT6 receptore u oboljelih od shizofrenije i akutnih ekstrapiramidalnih nuspojava antipsihotika haloperidola [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2020 [cited 2024 November 09] Available at: https://urn.nsk.hr/urn:nbn:hr:163:144566

IEEE

M. Grubor, "Povezanost polimorfizama gena za serotoninske 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C I 5-HT6 receptore u oboljelih od shizofrenije i akutnih ekstrapiramidalnih nuspojava antipsihotika haloperidola", Doctoral thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:163:144566

Cite this item: https://urn.nsk.hr/urn:nbn:hr:163:144566

Metadata

Title	Povezanost polimorfizama gena za serotoninske 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C I 5-HT6 receptore u oboljelih od shizofrenije i akutnih ekstrapiramidalnih nuspojava antipsihotika haloperidola
Title (english)	The association between serotonin receptor 5-HT1A, 5 HT1B, 5-HT2A, 5-HT2C and 5-HT6 gene polymorphisms and acute extrapyramidal side effects in haloperidol-treated patients with schizophrenia
Author	Mirko Grubor
Mentor	Dubravka Švob Štrac (mentor)
Mentor	Lidija Bach-Rojecky (komentor)
Committee member	Karmela Barišić (predsjednik povjerenstva)
Committee member	Nada Božina (član povjerenstva)
Committee member	Sanja Dabelić (član povjerenstva)
Granter	University of Zagreb Faculty of Pharmacy and Biochemistry (Department of pharmacology) Zagreb
Defense date and country	2020-10-26, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
Universal decimal classification (UDC)	615 - Pharmacology. Therapeutics. Toxicology
Abstract	Uvod: Shizofrenija je kronični psihijatrijski poremećaj koji zahtijeva cjeloživotno liječenje. Ekstrapiramidalne nuspojave (EPS) česte su nuspojave antipsihotičkih lijekova. Uz dopaminergički sustav, u razvoj EPS-ova mogu biti uključeni i serotonergički mehanizmi putem serotoninskih (5-HT) receptora. Svrha rada: Istražiti povezanost polimorfizama gena HTR1A, HTR1B, HTR2A, HTR2C i HTR6 s akutnim EPS-ovima u bolesnika sa shizofrenijom nakon terapije haloperidolom. Medode i ispitanici: Simpson Angusova ljestvica za EPS-ove (SAS), Barnesova ljestvica za akatiziju (BARS) i Ljestvica za ocjenu EPS simptoma (ESRS) korištene su za procjenu težine EPS-ova nakon dvotjedne terapije haloperidolom u 229 muškaraca s dijagnozom shizofrenije prema DSM-IV kriterijima. Genotipizacija je provedena lančanom reakcijom polimeraze u stvarnom vremenu, nakon izolacije DNA iz krvi. Rezultati: Značajne akutne EPS-ove prijavilo je 48,03 % bolesnika sa shizofrenijom. Nositelji TT genotipa HTR1B rs13212041 polimorfizma razvili su simptome akatizije nakon terapije haloperidolom učestalije i u težem obliku od nositelja CT genotipa i C alela. Primjećene su i značajne razlike između nositelja CC i CT genotipova HTR2A rs6313 polimorfizma u broju ESRS bodova za rigidnost, te između nositelja CC i TT genotipova HTR6 rs1805054 polimorfizma u broju SAS i ESRS bodova za tremor. HTR2C rs3813929- rs518147 haplotip TG bio je češći u bolesnika bez akutnih EPS-ova nego u bolesnika s akutnim EPS-ovima nakon terapije haloperidolom. Zaključak: Rezultati upućuju na genotipsku i haplotipsku povezanost pojedinih polimorfizama HTR1B, HTR2A, HTR2C i HTR6 gena s akutnim EPS-ovima izazvanim primjenom haloperidola u oboljelih od shizofrenije.
Abstract (english)	Backgorund: Schizophrenia is chronic psychiatric disorder requiring lifelong treatment. Extrapyramidal side effects (EPS) are common adverse drug reactions of antipsychotics. In addition to the dopaminergic system, serotonergic mechanisms via serotonin (5-HT) receptors might be also involved in the development of EPS. Aim of study: The aim of the study was to examine the associations of HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms with acute EPS in schizophrenia patients following haloperidol therapy. Methods and patients: Simpson Angus Rating Scale for EPS (SAS), Barnes Akathisia Rating Scale (BARS) and EPS Rating Scale (ESRS) were used to evaluate EPS severity in 229 schizophrenia-diagnosed males (DSM-IV criteria). Genotyping was performed using Real-Time PCR following extraction of blood DNA. Results: Significant acute EPS appeared in 48,03 % of schizophrenia patients. In the case of HTR1B rs13212041 polymorphism, carriers of TT genotype developed akathisia more often and with more severe symptoms following haloperidol therapy then carriers of CT genotype and C allele. Significant differences were observed between carriers of CC and CT genotypes of HTR2A rs6313 polymorphism in the number of ESRS scores for rigidity, and between carriers of CC and TT genotypes of HTR6 rs1805054 polymorphism in the number of SAS and ESRS scores for tremor. The HTR2C rs3813929-rs518147 TG haplotype was more frequent in patients without acute EPS than in patients who developed acute EPS after haloperidol therapy. Conclusion: Results suggest the genotypic and haplotypic association of selected polymorphisms in HTR1B, HTR2A, HTR2C and HTR6 genes with haloperidol-induced acute EPS in patients with schizophrenia.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:163:144566
Promotion	2021
Study programme	Title: Pharmacy and biochemistry Study programme type: university Study level: postgraduate Academic / professional title: doktor znanosti (doktor znanosti)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Created on	2021-05-19 08:52:35

Search form