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Scientific paper - Original scientific paper
Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery
Acta Pharmaceutica, 73 (2023), 4 (Special Issue); 691-707. https://doi.org/10.2478/acph-2023-0040
Peršec, Jasminka; Šribar, Andrej; Ilić, Monika; Mamić, Ivan; Kifer, Domagoj; Domijan, Ana-Marija; Maleš, Željan; Turčić, Petra

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Peršec, J., Šribar, A., Ilić, M., Mamić, I., Kifer, D., Domijan, A. M. ... Turčić, P. (2023). Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery. Acta Pharmaceutica, 73. (4 (Special Issue)), 691-707. doi: 10.2478/acph-2023-0040

Peršec, Jasminka, et al. "Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery." Acta Pharmaceutica, vol. 73, no. 4 (Special Issue), 2023, pp. 691-707. https://doi.org/10.2478/acph-2023-0040

Peršec, Jasminka, Andrej Šribar, Monika Ilić, Ivan Mamić, Domagoj Kifer, Ana Marija Domijan, Željan Maleš and Petra Turčić. "Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery." Acta Pharmaceutica 73, no. 4 (Special Issue) (2023): 691-707. https://doi.org/10.2478/acph-2023-0040

Peršec, J., et al. (2023) 'Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery', Acta Pharmaceutica, 73(4 (Special Issue)), pp. 691-707. doi: 10.2478/acph-2023-0040

Peršec J, Šribar A, Ilić M, Mamić I, Kifer D, Domijan AM, and sur.. Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery. Acta Pharmaceutica [Internet]. 2023 [cited 2024 November 22];73(4 (Special Issue)):691-707. doi: 10.2478/acph-2023-0040

J. Peršec, et al., "Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery", Acta Pharmaceutica, vol. 73, no. 4 (Special Issue), pp. 691-707, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:589050. [Accessed: 22 November 2024]

Metadata
Title (english)Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery
AuthorJasminka Peršec
AuthorAndrej Šribar
AuthorMonika Ilić
AuthorIvan Mamić
AuthorDomagoj Kifer
AuthorAna-Marija Domijan
AuthorŽeljan Maleš
AuthorPetra Turčić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of biophysics)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical botany)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
The aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to pre-operative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the post-operative level of pain, use of analgesics, inflammation, and oxidative stress. The study enrolled 42 patients who underwent elective thoracic surgery in a one-year period at the University Hospital Dubrava (Zagreb, Croatia). Based on a computer-generated randomization list the patients were assigned to the dexmedetomidine (n = 18) or dexamethasone (n = 24) group. Post-operatively, patients of dexmedetomidine group reported lower pain (VAS value 1 h post-surgery, 3.4 ± 2.7 vs. 5.4 ± 1.8, dexmedetomidine vs. dexamethasone, p < 0.01) and had lower analgesic requirements in comparison with dexamethasone group. Thus, dexmedetomidine in comparison with dexamethasone was more efficient in lowering pain and analgesia requirements 24 h after the surgery. On the contrary, dexamethasone had better anti-inflammatory properties (CRP level 24 h post-surgery, 131.9 ± 90.7 vs. 26.0 ± 55.2 mg L–1, dexmedetomidine vs. dexamethasone, p < 0.01). Both dexmedetomidine and dexamethasone exhibited antioxidant effects, however, their antioxidant properties should be further explored. The results of this study improve current knowledge of pain control in thoracic surgery.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 73, no. 4 (Special Issue), pp. 691-707
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2023-0040
URN:NBNurn:nbn:hr:163:589050
Publication2023
Document URLhttps://hrcak.srce.hr/308543
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-01-26 12:20:37