prikaz prve stranice dokumenta Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery
  Preuzmi
PDF 459.04 KB
Znanstveni rad - Izvorni znanstveni rad
Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery
Acta Pharmaceutica, 73 (2023), 4 (Special Issue); 691-707. https://doi.org/10.2478/acph-2023-0040
Peršec, Jasminka; Šribar, Andrej; Ilić, Monika; Mamić, Ivan; Kifer, Domagoj; Domijan, Ana-Marija; Maleš, Željan; Turčić, Petra

Institucijski repozitorij: Repozitorij Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Peršec, J., Šribar, A., Ilić, M., Mamić, I., Kifer, D., Domijan, A. M. ... Turčić, P. (2023). Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery. Acta Pharmaceutica, 73. (4 (Special Issue)), 691-707. doi: 10.2478/acph-2023-0040

Peršec, Jasminka, et al. "Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery." Acta Pharmaceutica, vol. 73, br. 4 (Special Issue), 2023, str. 691-707. https://doi.org/10.2478/acph-2023-0040

Peršec, Jasminka, Andrej Šribar, Monika Ilić, Ivan Mamić, Domagoj Kifer, Ana Marija Domijan, Željan Maleš i Petra Turčić. "Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery." Acta Pharmaceutica 73, br. 4 (Special Issue) (2023): 691-707. https://doi.org/10.2478/acph-2023-0040

Peršec, J., et al. (2023) 'Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery', Acta Pharmaceutica, 73(4 (Special Issue)), str. 691-707. doi: 10.2478/acph-2023-0040

Peršec J, Šribar A, Ilić M, Mamić I, Kifer D, Domijan AM, i sur.. Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery. Acta Pharmaceutica [Internet]. 2023. [pristupljeno 03.12.2024.];73(4 (Special Issue)):691-707. doi: 10.2478/acph-2023-0040

J. Peršec, et al., "Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery", Acta Pharmaceutica, vol. 73, br. 4 (Special Issue), str. 691-707, 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:589050. [Citirano: 03.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:163:589050
Podaci o radu
Naslov (engleski)Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery
AutorJasminka Peršec
AutorAndrej Šribar
AutorMonika Ilić
AutorIvan Mamić
AutorDomagoj Kifer
AutorAna-Marija Domijan
AutorŽeljan Maleš
AutorPetra Turčić
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za biofiziku)
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za farmaceutsku botaniku)
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za farmakologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
The aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to pre-operative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the post-operative level of pain, use of analgesics, inflammation, and oxidative stress. The study enrolled 42 patients who underwent elective thoracic surgery in a one-year period at the University Hospital Dubrava (Zagreb, Croatia). Based on a computer-generated randomization list the patients were assigned to the dexmedetomidine (n = 18) or dexamethasone (n = 24) group. Post-operatively, patients of dexmedetomidine group reported lower pain (VAS value 1 h post-surgery, 3.4 ± 2.7 vs. 5.4 ± 1.8, dexmedetomidine vs. dexamethasone, p < 0.01) and had lower analgesic requirements in comparison with dexamethasone group. Thus, dexmedetomidine in comparison with dexamethasone was more efficient in lowering pain and analgesia requirements 24 h after the surgery. On the contrary, dexamethasone had better anti-inflammatory properties (CRP level 24 h post-surgery, 131.9 ± 90.7 vs. 26.0 ± 55.2 mg L–1, dexmedetomidine vs. dexamethasone, p < 0.01). Both dexmedetomidine and dexamethasone exhibited antioxidant effects, however, their antioxidant properties should be further explored. The results of this study improve current knowledge of pain control in thoracic surgery.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Pharmaceutica
Brojčani podacivol. 73, br. 4 (Special Issue), str. 691-707
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2023-0040
URN:NBNurn:nbn:hr:163:589050
Datum objave publikacije2023
URL dokumentahttps://hrcak.srce.hr/308543
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-01-26 12:20:37