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master's thesis
Utjecaj bisfenola A na sadržaj polifenola u lukovicama običnog luka (Allium cepa L.)
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:629211
Đorđević, Anja
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical botany

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Đorđević, A. (2024). Utjecaj bisfenola A na sadržaj polifenola u lukovicama običnog luka (Allium cepa L.) (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:629211

Đorđević, Anja. "Utjecaj bisfenola A na sadržaj polifenola u lukovicama običnog luka (Allium cepa L.)." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:629211

Đorđević, Anja. "Utjecaj bisfenola A na sadržaj polifenola u lukovicama običnog luka (Allium cepa L.)." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:629211

Đorđević, A. (2024). 'Utjecaj bisfenola A na sadržaj polifenola u lukovicama običnog luka (Allium cepa L.)', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 06 October 2024, https://urn.nsk.hr/urn:nbn:hr:163:629211

Đorđević A. Utjecaj bisfenola A na sadržaj polifenola u lukovicama običnog luka (Allium cepa L.) [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2024 October 06] Available at: https://urn.nsk.hr/urn:nbn:hr:163:629211

A. Đorđević, "Utjecaj bisfenola A na sadržaj polifenola u lukovicama običnog luka (Allium cepa L.)", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:629211

Metadata
TitleUtjecaj bisfenola A na sadržaj polifenola u lukovicama običnog luka (Allium cepa L.)
Title (english)The effect of bisphenol A on polyphenol content in bulbs of common onion (Allium cepa L.)
AuthorAnja Đorđević
MentorAna-Marija Domijan (mentor)
Committee memberAna-Marija Domijan (predsjednik povjerenstva)
Committee memberLovorka Vujić (član povjerenstva)
Committee memberEmerik Galić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical botany)
Zagreb
Defense date and country2024-06-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Bisfenol A (BPA) ima široku primjenu te se stoga nalazi u okolišu u sve većoj koncentraciji. Zbog toga je izloženost BPA neminovna. Izloženost BPA povezuje se s nizom negativnih učinaka na zdravlje ljudi. Provode se brojna istraživanja na biljnom i na animalnom modelu kako bi se razjasnio mehanizam djelovanja BPA. Cilj ovog istraživanja bio je ispitati učinak BPA na razinu polifenola i njegovu akumulaciju u biljkama. Kao biljni model korišten je običan luk (Allium cepa L.). Luk (šest skupina po 10 lukovica) izložen je otopinama BPA u rasponu koncentracija 1-50 mg/L. U istraživanje je uključena skupina lukovica koja je bila izložena samo destiliranoj vodi (10 lukovica, kontrola). Nakon trodnevnog izlaganja u lukovicama luka određena je razina BPA pomoću FTIR-a, a sadržaj ukupnih fenola (TF), ukupnih flavnola (TFL) i ukupnih hidroksicimetnih kiselina (THC) spektrofotometrijski. Rezultati istraživanja pokazali su da se BPA može detektirati u lukovicama luka već i nakon tri dana izloženosti otopinama BPA. Također, izloženost BPA dovela je do smanjenja sadržaja TF i THC ovisno o koncentraciji BPA. Stoga se može zaključiti da biljke akumuliraju BPA te da BPA u biljkama uzrokuje oksidacijski stres koji se očituje smanjenjem sadržaja polifenola koji se troše u obrani od stresa.
Abstract (english)
Bisphenol A (BPA) has numerous uses and as consequence its concentration in the environment is increasing. That makes exposure to BPA inevitable. Human exposure to BPA is associated with a range of adverse effects. Numerous studies are conducting in both, plant and animal models in order to clarify the mechanisms of BPA action. The aim of this study was to investigate the effect of BPA on the level of polyphenols and its accumulation in plants. As study model common onion (Allium cepa L.) was used. Onions (six groups of 10 bulbs each) were exposed to BPA solutions in concentrations range 1-50 mg/L. The study also included a control group (one group of 10 bulbs) that was exposed to distilled water. After three days of exposure, in the onion bulbs the BPA levels were determined using FTIR, while the total phenol (TF), total flavanol (TFL), and total hydroxycinnamic acid (THC) contents were determined spectrophotometrically. The results of this study showed that BPA could be detected in the onion bulbs even after three days of exposure to BPA. Additionally, exposure to BPA led to a reduction in TF and THC content, that was depended on the BPA concentration. Therefore, it can be concluded that plants accumulate BPA and that BPA in plants causes oxidative stress, which is manifested by a reduction in polyphenol content that is consumed for defence against oxidative stress.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:629211
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-25 10:25:19