prikaz prve stranice dokumenta Teški metali u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva
Embargo period 2026-07-17
master's thesis
Teški metali u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:011231
Štefiček, Tomislav
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical analysis

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Štefiček, T. (2024). Teški metali u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:011231

Štefiček, Tomislav. "Teški metali u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:011231

Štefiček, Tomislav. "Teški metali u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:011231

Štefiček, T. (2024). 'Teški metali u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:011231

Štefiček T. Teški metali u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:011231

T. Štefiček, "Teški metali u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:011231

Metadata
TitleTeški metali u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva
Title (english)Heavy metals in formulated dietary supplements for the treatment of inflammatory bowel diseases
AuthorTomislav Štefiček
MentorDaniela Amidžić Klarić (mentor)
Committee memberDaniela Amidžić Klarić (predsjednik povjerenstva)
Committee memberAna Mornar Turk (član povjerenstva)
Committee memberAna Karković Marković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical analysis)
Zagreb
Defense date and country2024-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Upalne bolesti crijeva su teške bolesti s nuspojavama koje utječu na svakodnevni život pacijenata koji od njih boluju. Mnogi uz standardnu farmakoterapiju uzimaju i razne dodatke prehrani. Među njima su i biljni pripravci kurkume, justicije i indijskog tamjanovca koji se koriste za ublažavanje simptoma upalnih bolesti crijeva. Osim bioaktivnih molekula koje se prirodno nalaze u ovim biljkama i koje pokazuju farmakološki učinak, mogu se naći i razna onečišćenja kao naprimjer teški metali.. Teški metali nemaju fiziološku funkciju u ljudskom tijelu i osim toga imaju potencijal biti iznimno toksični. U ovom radu se određivao sadržaj olova, arsena i cinka u 12 dodatak prehrani s ciljem procjene sigurnosti njihove primjene.. Koncentracija metala je određena atomskom apsorpcijskom spektrometrijom grafitnom tehnikom nakon prvotne mikrovalne digestije uzoraka. Izračunata je količina teških metala koja bi se unijela u jednoj dozi i dnevno prateći upute proizvođača i od 12 uzoraka jedan od njih prelazi dozvoljeni dnevni unos za olovo prema ICH smjernicama. U pripravcima su dokazane varijabilne koncentracije teških metala što ukazuje na potrebu temeljite kontrole sigurnosti ovakvih dodataka prehrani.
Abstract (english)
Inflammatory bowel diseases are crippling diseases that have a severe impact on the everyday life of its patients. Many such patients take various dietary supplements in addition to their standard pharmacotherapy. Among them exist herbal supplements based on turmeric, green chiretta and Indian frankincense which are used to alleviate the symptoms of inflammatory bowel diseases. In addition to the bioactive molecules that are naturally found in these plants and that show a pharmacological effect, various pollutants can be found, such as heavy metals. Heavy metals have no physiological function in the human body and, in addition, have the potential to be extremely toxic. In this study, the content of lead, arsenic and zinc in 12 dietary supplements was determined with the aim of assessing the safety of their use. Metal concentration was determined by atomic absorption spectrometry using the graphite technique after initial microwave digestion of the samples. The amount of heavy metals that would be ingested in a singular and daily dose following the recommended intake by the manufacturer was calculated, and out of 12 samples, one of them exceeded the permitted daily intake for lead according to ICH guidelines. Variable concentrations of heavy metals have been proven in the preparations, which indicates the need for thorough control of the safety of such dietary supplements.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:011231
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2026-07-17
Terms of useLicence In copyright icon
Created on2024-09-27 10:44:48