prikaz prve stranice dokumenta Određivanje metalnih onečišćenja u dodacima prehrani za liječenje upalnih bolesti crijeva primjenom GFAAS tehnike
Embargo period 2026-07-12
master's thesis
Određivanje metalnih onečišćenja u dodacima prehrani za liječenje upalnih bolesti crijeva primjenom GFAAS tehnike
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:230734
Dević, Bernarda
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical analysis

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Dević, B. (2024). Određivanje metalnih onečišćenja u dodacima prehrani za liječenje upalnih bolesti crijeva primjenom GFAAS tehnike (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:230734

Dević, Bernarda. "Određivanje metalnih onečišćenja u dodacima prehrani za liječenje upalnih bolesti crijeva primjenom GFAAS tehnike." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:230734

Dević, Bernarda. "Određivanje metalnih onečišćenja u dodacima prehrani za liječenje upalnih bolesti crijeva primjenom GFAAS tehnike." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:230734

Dević, B. (2024). 'Određivanje metalnih onečišćenja u dodacima prehrani za liječenje upalnih bolesti crijeva primjenom GFAAS tehnike', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:230734

Dević B. Određivanje metalnih onečišćenja u dodacima prehrani za liječenje upalnih bolesti crijeva primjenom GFAAS tehnike [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:163:230734

B. Dević, "Određivanje metalnih onečišćenja u dodacima prehrani za liječenje upalnih bolesti crijeva primjenom GFAAS tehnike", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:230734

Metadata
TitleOdređivanje metalnih onečišćenja u dodacima prehrani za liječenje upalnih bolesti crijeva primjenom GFAAS tehnike
Title (english)Determination of metal impurities in dietary supplements for the treatment of inflammatory bowel diseases using the GFAAS technique
AuthorBernarda Dević
MentorDaniela Amidžić Klarić (mentor)
Committee memberDaniela Amidžić Klarić (predsjednik povjerenstva)
Committee memberKristina Pavić (član povjerenstva)
Committee memberNajda Rudman (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical analysis)
Zagreb
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Primjena dodataka prehrani koji sadrže biljne sastavnice u stalnom je porastu, a zahtjevi za kontinuiranu kontrolu sigurnosti istih ne postoje. Kurkuma, justicija, indijski tamjanovac i crni papar sadrže biološki aktivne tvari koje pokazuju pozitivan učinak na tijek upalnih bolesti crijeva. Navedene biljke iz tla akumuliraju, u svojim podzemnim i nadzemnim organima, teške metale koji imaju negativan učinak na zdravlje ljudi. Određen je sadržaj kobalta, nikla, srebra i selena u 15 dodataka prehrani različita porijekla metodom atomske apsorpcijske spektrometrije, grafitnom tehnikom. Kobalt i selen imaju važne uloge u organizmu, no u prekomjernim količinama ostvaruju štetno djelovanje. Nikal i srebro štetni su već pri malim količinama. Analizi sadržaja metala prethodila je mikrovalna digestija. Koncentracije analiziranih metala ispod su maksimalno dozvoljenog dnevnog oralnog unosa za metalna onečišćenja koji navode ICH smjernice iz čega se zaključuje da analizirani dodaci prehrani ne predstavljaju rizik za zdravlje. Pretraživanjem dostupne stručne i znanstvene literature, rezultati rada uspoređeni su s prethodnim istraživanjima na istim biljkama te nisu uočene statistički značajne razlike u sadržaju metala u biljkama.
Abstract (english)
The use of dietary supplements containing herbal components is constantly increasing, yet the requirements for continuous safety control of these supplements do not exist. Turmeric, Indian frankincense, Green chiretta, and Black Pepper contain biologically active substances that show a positive effect on the course of inflammatory bowel diseases. These plants accumulate heavy metals from the soil in their underground and aboveground organs, which have a negative impact on human health. The content of cobalt, nickel, silver, and selenium in 15 dietary supplements of various origins was determined using atomic absorption spectrometry with graphite furnace technique. Cobalt and selenium play essential roles in the body, but in excessive amounts, they have harmful effects. Nickel and silver are harmful even in small amounts. Microwave digestion preceded the analysis of metal content. The concentrations of the analyzed metals are below the permitted daily oral intake for elemental impurities as stated by the ICH guidelines, leading to the conclusion that the investigated dietary supplements do not pose a health risk. By searching the available professional and scientific literature, the results of this work were compared with previous studies on the same plants, and no statistically significant differences in metal content were observed in plants.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:230734
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2026-07-12
Terms of useLicence In copyright icon
Created on2024-10-09 12:52:47