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Scientific paper - Original scientific paper
GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD
Acta Pharmaceutica, 64 (2014), 1; 117-129. https://doi.org/10.2478/acph-2014-0003
Žuntar, Irena; Petlevski, Roberta; Dodig, Slavica; Popović-Grle, Sanja

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Žuntar, I., Petlevski, R., Dodig, S. & Popović Grle, S. (2014). GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD. Acta Pharmaceutica, 64. (1), 117-129. doi: 10.2478/acph-2014-0003

Žuntar, Irena, et al. "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD." Acta Pharmaceutica, vol. 64, no. 1, 2014, pp. 117-129. https://doi.org/10.2478/acph-2014-0003

Žuntar, Irena, Roberta Petlevski, Slavica Dodig and Sanja Popović Grle. "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD." Acta Pharmaceutica 64, no. 1 (2014): 117-129. https://doi.org/10.2478/acph-2014-0003

Žuntar, I., et al. (2014) 'GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD', Acta Pharmaceutica, 64(1), pp. 117-129. doi: 10.2478/acph-2014-0003

Žuntar I, Petlevski R, Dodig S, Popović Grle S. GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD. Acta Pharmaceutica [Internet]. 2014 March 31 [cited 2024 November 09];64(1):117-129. doi: 10.2478/acph-2014-0003

I. Žuntar, R. Petlevski, S. Dodig and S. Popović Grle, "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD", Acta Pharmaceutica, vol. 64, no. 1, pp. 117-129, March 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:326391. [Accessed: 09 November 2024]

Metadata
Title (english)GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD
AuthorIrena Žuntar
AuthorRoberta Petlevski
AuthorSlavica Dodig
AuthorSanja Popović-Grle
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medical biochemistry and haematology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
The aim of this study was to test the hypothesis that glutathione-S-transferase (GST) genotypes were associated with COPD. GSTP1, GSTM1 and GSTT1 genotypes were determined by DNA methods and GST activity spectrophotometrically in older male Caucasian Croats (non-smokers, ex-smokers, and smokers) with stable COPD (n = 30) and sex/age matched controls (n = 60). The distribution of GSTP1 genotypes and alleles in controls vs. COPD showed a statistical difference (p < 0.05). The odds ratio of CC/CT+TT (wild type GSTP1 exon 6 vs. joint heterozygous and mutant homozygous GSTP1 exon 6) was 10.000 and statistically different (p = 0.002). In this study, the GSTP1 mutant genotype of exon 5 (GG), as well as GSTP1 mutant and heterozygous genotypes of exon 6 (TT and CT), were suggested to be genetic contributors to COPD susceptibility. Null GSTM1, null GSTT1 and joint GSTM1/GSTT1 null genotypes were not disease associated. Serum GST was not associated with GST genotypes and COPD or smoking history in our study subjects. Conclusions drawn from the study should be further supported and clarified by studies with larger sample sizes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 64, no. 1, pp. 117-129
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2014-0003
URN:NBNurn:nbn:hr:163:326391
Publication2014-03-31
Document URLhttp://hrcak.srce.hr/113582
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-02-09 11:24:00