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GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD
Acta Pharmaceutica, 64 (2014), 1; 117-129. https://doi.org/10.2478/acph-2014-0003
Žuntar, Irena; Petlevski, Roberta; Dodig, Slavica; Popović-Grle, Sanja

Institucijski repozitorij: Repozitorij Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu

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Žuntar, I., Petlevski, R., Dodig, S. i Popović Grle, S. (2014). GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD. Acta Pharmaceutica, 64. (1), 117-129. doi: 10.2478/acph-2014-0003

Žuntar, Irena, et al. "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD." Acta Pharmaceutica, vol. 64, br. 1, 2014, str. 117-129. https://doi.org/10.2478/acph-2014-0003

Žuntar, Irena, Roberta Petlevski, Slavica Dodig i Sanja Popović Grle. "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD." Acta Pharmaceutica 64, br. 1 (2014): 117-129. https://doi.org/10.2478/acph-2014-0003

Žuntar, I., et al. (2014) 'GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD', Acta Pharmaceutica, 64(1), str. 117-129. doi: 10.2478/acph-2014-0003

Žuntar I, Petlevski R, Dodig S, Popović Grle S. GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD. Acta Pharmaceutica [Internet]. 31.03.2014. [pristupljeno 10.11.2024.];64(1):117-129. doi: 10.2478/acph-2014-0003

I. Žuntar, R. Petlevski, S. Dodig i S. Popović Grle, "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD", Acta Pharmaceutica, vol. 64, br. 1, str. 117-129, Ožujak 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:326391. [Citirano: 10.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:163:326391
Podaci o radu
Naslov (engleski)GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD
AutorIrena Žuntar
AutorRoberta Petlevski
AutorSlavica Dodig
AutorSanja Popović-Grle
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za medicinsku biokemiju i hematologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
The aim of this study was to test the hypothesis that glutathione-S-transferase (GST) genotypes were associated with COPD. GSTP1, GSTM1 and GSTT1 genotypes were determined by DNA methods and GST activity spectrophotometrically in older male Caucasian Croats (non-smokers, ex-smokers, and smokers) with stable COPD (n = 30) and sex/age matched controls (n = 60). The distribution of GSTP1 genotypes and alleles in controls vs. COPD showed a statistical difference (p < 0.05). The odds ratio of CC/CT+TT (wild type GSTP1 exon 6 vs. joint heterozygous and mutant homozygous GSTP1 exon 6) was 10.000 and statistically different (p = 0.002). In this study, the GSTP1 mutant genotype of exon 5 (GG), as well as GSTP1 mutant and heterozygous genotypes of exon 6 (TT and CT), were suggested to be genetic contributors to COPD susceptibility. Null GSTM1, null GSTT1 and joint GSTM1/GSTT1 null genotypes were not disease associated. Serum GST was not associated with GST genotypes and COPD or smoking history in our study subjects. Conclusions drawn from the study should be further supported and clarified by studies with larger sample sizes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Pharmaceutica
Brojčani podacivol. 64, br. 1, str. 117-129
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2014-0003
URN:NBNurn:nbn:hr:163:326391
Datum objave publikacije2014-03-31
URL dokumentahttp://hrcak.srce.hr/113582
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-02-09 11:24:00