prikaz prve stranice dokumenta Primaquine-NSAID twin drugs: synthesis, radical scavenging, antioxidant and Fe2+ chelating activity
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Scientific paper - Original scientific paper
Primaquine-NSAID twin drugs: synthesis, radical scavenging, antioxidant and Fe2+ chelating activity
Acta Pharmaceutica, 60 (2010), 3; 325-337. https://doi.org/10.2478/v10007-010-0024-9
Rajić, Zrinka; Zovko Končić, Marijana; Miloloža, Kristina; Perković, Ivana; Butula, Ivan; Bucar, Franz; Zorc, Branka

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Rajić, Z., Zovko Končić, M., Miloloža, K., Perković, I., Butula, I., Bucar, F. & Zorc, B. (2010). Primaquine-NSAID twin drugs: synthesis, radical scavenging, antioxidant and Fe2+ chelating activity. Acta Pharmaceutica, 60. (3), 325-337. doi: 10.2478/v10007-010-0024-9

Rajić, Zrinka, et al. "Primaquine-NSAID twin drugs: synthesis, radical scavenging, antioxidant and Fe2+ chelating activity." Acta Pharmaceutica, vol. 60, no. 3, 2010, pp. 325-337. https://doi.org/10.2478/v10007-010-0024-9

Rajić, Zrinka, Marijana Zovko Končić, Kristina Miloloža, Ivana Perković, Ivan Butula, Franz Bucar and Branka Zorc. "Primaquine-NSAID twin drugs: synthesis, radical scavenging, antioxidant and Fe2+ chelating activity." Acta Pharmaceutica 60, no. 3 (2010): 325-337. https://doi.org/10.2478/v10007-010-0024-9

Rajić, Z., et al. (2010) 'Primaquine-NSAID twin drugs: synthesis, radical scavenging, antioxidant and Fe2+ chelating activity', Acta Pharmaceutica, 60(3), pp. 325-337. doi: 10.2478/v10007-010-0024-9

Rajić Z, Zovko Končić M, Miloloža K, Perković I, Butula I, Bucar F, and sur.. Primaquine-NSAID twin drugs: synthesis, radical scavenging, antioxidant and Fe2+ chelating activity. Acta Pharmaceutica [Internet]. 2010 September 01 [cited 2024 December 23];60(3):325-337. doi: 10.2478/v10007-010-0024-9

Z. Rajić, et al., "Primaquine-NSAID twin drugs: synthesis, radical scavenging, antioxidant and Fe2+ chelating activity", Acta Pharmaceutica, vol. 60, no. 3, pp. 325-337, September 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:692895. [Accessed: 23 December 2024]

Metadata
Title (english)Primaquine-NSAID twin drugs: synthesis, radical scavenging, antioxidant and Fe2+ chelating activity
Title (croatian)Dvojni lijekovi primakina i nesteroidnih protuupalnih lijekova: Sinteza, hvatanje slobodnih radikala, antioksidativno djelovanje i keliranje Fe2+ iona
AuthorZrinka Rajić
AuthorMarijana Zovko Končić
AuthorKristina Miloloža
AuthorIvana Perković
AuthorIvan Butula
MBZ: 6372
AuthorFranz Bucar
AuthorBranka Zorc
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacognosy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Novel primaquine conjugates with non-steroidal anti-inflammatory drugs (PQ-NSAIDs, 4a-h) were prepared, fully chemically characterized and screened for radical scavenging and antioxidant activities. The synthetic procedure leading to twin drugs 4a-h involved two steps: i) preparation of NSAID benzotriazolides 3a-h from the corresponding NSAID (ibuprofen, ketoprofen, fenoprofen, ketoprofen hydroxy and methylene analogues, diclofenac or indomethacin) and benzotriazole carboxylic acid chloride (BtCOCl, 1), ii) reaction of intermediates 3a-h with PQ. The prepared PQ-NSAIDs exerted moderate activities in the DPPH free radical test and -carotene-linoleic acid assay. Moreover, ketoprofen derivatives 4d and 4b demonstrated a notable Fe2+ chelating ability as well. On the other hand, negligible antiproliferative and antituberculotic effects of conjugates 4a-h were observed.
Abstract (croatian)
U radu je opisana sinteza novih konjugata primakina s nesteroidnim protuupalnim lijekovima (PQ-NSAIDs, 4a-h), njihova potpuna karakterizacija te testiranje sposobnosti hvatanja slobodnih radikala i antioksidativnog djelovanja. Sintetski postupak za pripravu dvojnih lijekova 4a-h uključuje dva koraka: i) pripravu NSAID-benzotriazolida 3a-h iz odgovarajućih nesteroidnih protuupalnih lijekova (ibuprofena, ketoprofena, fenoprofena, hidroksi i metilenskih analoga ketoprofena, diklofenaka i indometacina) i klorida 1-benzotriazol karboksilne kiseline (BtCOCl, 1), ii) reakciju intermedijera 3a-h s primakinom. Novi PQ-NSAID konjugati pokazuju umjerenu sposobnost hvatanja slobodnih radikala u DPPH testu te umjereno antioksidativno djelovanje u pokusu s -karotenom i linoleinskom kiselinom. Osim toga, derivati ketoprofena 4d i 4b imaju primjetnu sposobnost keliranja Fe2+ iona. Svi konjugati 4a-h pokazuju vrlo slabo antiproliferativno i antituberkulotsko djelovanje.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 60, no. 3, pp. 325-337
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/v10007-010-0024-9
URN:NBNurn:nbn:hr:163:692895
Publication2010-09-01
Document URLhttps://hrcak.srce.hr/53494
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-02-14 10:43:03