prikaz prve stranice dokumenta Genetic frequencies of paraoxonase 1 gene polymorphisms in Croatian population
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Scientific paper - Original scientific paper
Genetic frequencies of paraoxonase 1 gene polymorphisms in Croatian population
Croatica Chemica Acta, 81 (2008), 1; 105-111. urn:nbn:hr:163:647455
Grdić, Marija; Barišić, Karmela; Rumora, Lada; Salamunić, Ilza; Tadijanović, Milena; Žanić Grubišić, Tihana; Pšikalova, Renata; Flegar-Meštrić, Zlata; Juretić, Dubravka

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Grdić, M., Barišić, K., Rumora, L., Salamunić, I., Tadijanović, M., Žanić Grubišić, T. ... Juretić, D. (2008). Genetic frequencies of paraoxonase 1 gene polymorphisms in Croatian population. Croatica Chemica Acta, 81. (1), 105-111. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:647455

Grdić, Marija, et al. "Genetic frequencies of paraoxonase 1 gene polymorphisms in Croatian population." Croatica Chemica Acta, vol. 81, no. 1, 2008, pp. 105-111. https://urn.nsk.hr/urn:nbn:hr:163:647455

Grdić, Marija, Karmela Barišić, Lada Rumora, Ilza Salamunić, Milena Tadijanović, Tihana Žanić Grubišić, Renata Pšikalova, Zlata Flegar Meštrić and Dubravka Juretić. "Genetic frequencies of paraoxonase 1 gene polymorphisms in Croatian population." Croatica Chemica Acta 81, no. 1 (2008): 105-111. https://urn.nsk.hr/urn:nbn:hr:163:647455

Grdić, M., et al. (2008) 'Genetic frequencies of paraoxonase 1 gene polymorphisms in Croatian population', Croatica Chemica Acta, 81(1), pp. 105-111. Available at: https://urn.nsk.hr/urn:nbn:hr:163:647455 (Accessed 22 November 2024)

Grdić M, Barišić K, Rumora L, Salamunić I, Tadijanović M, Žanić Grubišić T, and sur.. Genetic frequencies of paraoxonase 1 gene polymorphisms in Croatian population. Croatica Chemica Acta [Internet]. 2008 April 15 [cited 2024 November 22];81(1):105-111. Available at: https://urn.nsk.hr/urn:nbn:hr:163:647455

M. Grdić, et al., "Genetic frequencies of paraoxonase 1 gene polymorphisms in Croatian population", Croatica Chemica Acta, vol. 81, no. 1, pp. 105-111, April 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:647455. [Accessed: 22 November 2024]

Metadata
Title (english)Genetic frequencies of paraoxonase 1 gene polymorphisms in Croatian population
AuthorMarija Grdić
AuthorKarmela Barišić
AuthorLada Rumora
AuthorIlza Salamunić
AuthorMilena Tadijanović
AuthorTihana Žanić Grubišić
AuthorRenata Pšikalova
AuthorZlata Flegar-Meštrić
AuthorDubravka Juretić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medical biochemistry and haematology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract (english)
Paraoxonase 1 (PON1), a HDL-associated enzyme, is believed to contribute to the protective effects of HDL by decreasing the generation of lipid peroxidation products during the process of LDL oxidation. It has been reported that polymorphisms in promoter and coding regions of the pon1 gene could affect PON1 activity. The aim of this study was to determine the frequencies of pon1 polymorphisms Q192R, L55M and –108C>T and their influence on PON1 activity in healthy population of Croatia. The following genotype frequencies were determined: 60 % QQ, 34 % QR, 6 % RR for Q192R; 44 % LL, 43 % LM, 13 % MM for L55M; 30 % CC, 48 % CT, 22 % TT for –108C>T polymorphism. Genotypes RR, LL and CC were found to be associated with higher PON1 activity. The most frequent genotypes in healthy Croatian population were QQ, CT and equally present LL and LM.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 81, no. 1, pp. 105-111
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:647455
Publication2008-04-15
Document URLhttps://hrcak.srce.hr/23398
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-05-11 11:33:11