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undergraduate thesis
Čaperon Hsp90 – uloge u smatanju proteina i pokretanju noviteta u evoluciji
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:994660
Verbanac, Ana
University of Zagreb
Faculty of Science
Department of Biology
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Verbanac, A. (2022). Čaperon Hsp90 – uloge u smatanju proteina i pokretanju noviteta u evoluciji (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:994660

Verbanac, Ana. "Čaperon Hsp90 – uloge u smatanju proteina i pokretanju noviteta u evoluciji." Undergraduate thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:994660

Verbanac, Ana. "Čaperon Hsp90 – uloge u smatanju proteina i pokretanju noviteta u evoluciji." Undergraduate thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:994660

Verbanac, A. (2022). 'Čaperon Hsp90 – uloge u smatanju proteina i pokretanju noviteta u evoluciji', Undergraduate thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, accessed 27 July 2024, https://urn.nsk.hr/urn:nbn:hr:217:994660

Verbanac A. Čaperon Hsp90 – uloge u smatanju proteina i pokretanju noviteta u evoluciji [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 July 27] Available at: https://urn.nsk.hr/urn:nbn:hr:217:994660

A. Verbanac, "Čaperon Hsp90 – uloge u smatanju proteina i pokretanju noviteta u evoluciji", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb; University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:994660

Metadata
TitleČaperon Hsp90 – uloge u smatanju proteina i pokretanju noviteta u evoluciji
Title (english)Chaperone Hsp90 – Roles in Protein Folding and Establishment of Novelties in Evolution
AuthorAna Verbanac
MentorMarko Močibob (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2022-09-21, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Čaperon Hsp90 jedan je od ključnih regulatora proteostaze pod normalnim i stresnim uvjetima za eukariotsku stanicu. Proteini iz obitelji Hsp90 pronađeni su u bakterijama, citosolu, endoplazmatskom retikulumu, mitohondriju i kloroplastu. Svi homolozi imaju slične strukture i funkcije zato što je riječ o vrlo konzerviranoj obitelji proteina. Sa svojim supstratima stvara komplekse te omogućuje konformacijske rearanžmane i poprimanje aktivne strukture proteina supstrata. Uz njih, bitnu ulogu imaju kočaperoni koji interagiraju sa čaperonom i reguliraju ATPaznu aktivnost, konformacijski ciklus Hsp90 dimera i interakciju sa drugim čaperonima. Hsp90 može imati i ulogu puferiranja i potenciranja genetičke varijacije i poticanja noviteta u evoluciji. Razumijevanje dinamike Hsp90 i kočaperona omogućuje razumijevanje smatanja proteina, ali i razvijanje metoda za liječenje neurodegenerativnih bolesti uzrokovanih agregacijama proteina.
Abstract (english)
Chaperone Hsp90 is one of key regulators of proteostasis under both physiological and stress conditions in eukaryotic cells. Members of Hsp90 protein family can be found in bacteria, cytosol, endoplasmatic reticulum, mitochondria and chloroplast. All homologs exhibit similar structures and functions because Hsp90 family is highly conserved. It forms complexes with its substrates and enables their conformational rearrangements and gaining of an active protein structure. An important role is played by co-chaperones that interact with the chaperone and regulate ATPase activity, the conformational cycle of the Hsp90 dimer and interaction with other chaperones. Hsp90 can also play the role of buffering and potentiating genetic variations and stimulating novelty in evolution. Understanding the dynamics of Hsp90 and co-chaperones enables the understanding of protein folding, but also the development of methods for the treatment of neurodegenerative diseases caused by protein aggregation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:994660
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-13 11:45:27