prikaz prve stranice dokumenta Priprava N,O-acetalnih derivata izoindolinona s prirodnim alkoholima
Embargo period 2025-02-21
master's thesis
Priprava N,O-acetalnih derivata izoindolinona s prirodnim alkoholima
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:256501
Čikulin, Kristina
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Čikulin, K. (2023). Priprava N,O-acetalnih derivata izoindolinona s prirodnim alkoholima (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:256501

Čikulin, Kristina. "Priprava N,O-acetalnih derivata izoindolinona s prirodnim alkoholima." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:256501

Čikulin, Kristina. "Priprava N,O-acetalnih derivata izoindolinona s prirodnim alkoholima." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:256501

Čikulin, K. (2023). 'Priprava N,O-acetalnih derivata izoindolinona s prirodnim alkoholima', Master's thesis, University of Zagreb, Faculty of Science, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:256501

Čikulin K. Priprava N,O-acetalnih derivata izoindolinona s prirodnim alkoholima [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:256501

K. Čikulin, "Priprava N,O-acetalnih derivata izoindolinona s prirodnim alkoholima", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:256501

Metadata
TitlePriprava N,O-acetalnih derivata izoindolinona s prirodnim alkoholima
Title (english)Synthesis of isoindolinone-derived N,O-acetals with natural alcohols
AuthorKristina Čikulin
MentorMatija Gredičak (mentor)
Committee memberĐani Škalamera (predsjednik povjerenstva)
Committee memberTajana Begović (član povjerenstva)
Committee memberIva Juranović Cindrić (član povjerenstva)
Committee memberŽeljka Car (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2023-02-21, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U radu je prikazana priprava N,O-acetalnih derivata izoindolinona, u kojima su izvor eterske komponente bili prirodni alkoholi, poput borneola, 1-tetradekanola i izopropilidenima zaštićeni derivat galaktoze. Istraživanja su pokazala da su N,O-acetali važni strukturni motivi i sintetski intermedijeri raznim prirodnim spojevim i farmaceutskim lijekovima. Također, izoindolinonski derivati N,O-acetala poznati su inhibitori MDM2-p53 protein-protein interakcija. U prvoj fazi ovog istraživačkog rada pripremljeni su 3-supstituirani-3-hidroksiizoindolinoni adicijom Grignardovog reagensa, reakcijom izmjene halogen-litij. Na pripravljenim spojevima uvedena je N,O-acetalna podjedinica korištenjem serije primarnih i sekundarnih alkohola kao nukleofila.
Abstract (english)
The preparation of N,O-acetal-derived isoindolinones is described, in which the source of the ether component are natural alcohols, such as borneol, 1-tetradecanol, and isopropylidene protected derivatives of galactose. Research has shown that N,O-acetals are important structural motifs and synthetic intermediates in various natural compounds and commercially available drugs. Isoindolinone N,O-acetal derivatives are known inhibitors of MDM2-p53 protein-protein interactions. In the first phase of this work, 3-substituted-3-hydroxyisoindolinones were prepared by addition of Grignard reagent, halogen-lithium exchange reaction. The N,O-acetal subunit was introduced into the prepared compounds using a series of primary and secondary alcohols as nucleophiles.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:256501
ProjectNumber: IP-2018-01-4053
Title: Nove strategije za pripravu tetrasupstituiranih kiralnih centara: asimetrične katalitičke reakcije usmjerene protuanionom
Acronym: NSYNC-ACDC
Leader: Matija Gredičak
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-02-21
Terms of useLicence In copyright icon
Created on2023-03-31 11:44:10