prikaz prve stranice dokumenta Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes
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Scientific paper - Original scientific paper
Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes
Biophysical Journal, 122 (2023), 4; 632-645. https://doi.org/10.1016/j.bpj.2023.01.017
Ban, Ivana; Tomašić, Lucija; Trakala, Marianna; Tolić, Iva M.; Pavin, Nenad

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Ban, I., Tomašić, L., Trakala, M., Tolić, I. M. & Pavin, N. (2023). Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes. Biophysical Journal, 122. (4), 632-645. doi: 10.1016/j.bpj.2023.01.017

Ban, Ivana, et al. "Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes." Biophysical Journal, vol. 122, no. 4, 2023, pp. 632-645. https://doi.org/10.1016/j.bpj.2023.01.017

Ban, Ivana, Lucija Tomašić, Marianna Trakala, Iva M. Tolić and Nenad Pavin. "Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes." Biophysical Journal 122, no. 4 (2023): 632-645. https://doi.org/10.1016/j.bpj.2023.01.017

Ban, I., et al. (2023) 'Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes', Biophysical Journal, 122(4), pp. 632-645. doi: 10.1016/j.bpj.2023.01.017

Ban I, Tomašić L, Trakala M, Tolić IM, Pavin N. Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes. Biophysical Journal [Internet]. 2023 [cited 2025 February 18];122(4):632-645. doi: 10.1016/j.bpj.2023.01.017

I. Ban, L. Tomašić, M. Trakala, I. M. Tolić and N. Pavin, "Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes", Biophysical Journal, vol. 122, no. 4, pp. 632-645, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:276672. [Accessed: 18 February 2025]

Metadata
Title (english)Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes
AuthorIvana Ban
AuthorLucija Tomašić
AuthorMarianna Trakala
AuthorIva M. Tolić
AuthorNenad Pavin
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Mathematics
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Interdisciplinary Natural Sciences
Abstract (english)
Most tumors have abnormal karyotypes, which arise from mistakes during mitotic division of healthy euploid cells and evolve through numerous complex mechanisms. In a recent mouse model with increased chromosome missegregation, chromosome gains dominate over losses both in pretumor and tumor tissues, whereas T-cell lymphomas are characterized by gains of chromosomes 14 and 15. However, the quantitative understanding of clonal selection leading to tumor karyotype evolution remains unknown. Here we show, by introducing a mathematical model based on a concept of a macro-karyotype, that tumor karyotypes can be explained by proliferation-driven evolution of aneuploid cells. In pretumor cells, increased apoptosis and slower proliferation of cells with monosomies lead to predominant chromosome gains over losses. Tumor karyotypes with gain of one chromosome can be explained by karyotype-dependent proliferation, whereas, for those with two chromosomes, an interplay with karyotype-dependent apoptosis is an additional possible pathway. Thus, evolution of tumor-specific karyotypes requires proliferative advantage of specific aneuploid karyotypes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiophysical Journal
Numberingvol. 122, no. 4, pp. 632-645
p-ISSN0006-3495
DOIhttps://doi.org/10.1016/j.bpj.2023.01.017
URN:NBNurn:nbn:hr:217:276672
Publication2023
ProjectNumber: 8551580
Title (english): Molecular origins of aneuploidies in healthy and diseased human tissues
Acronym: ANEUPLOIDY
Leader: Iva Marija Tolić; Nenad Pavin
Jurisdiction: eu
ProjectNumber: IP-2019-04-5967
Title (croatian): Ravnoteža sila i momenta sila u diobenom vretenu
Title (english): Balance of forces and torques in the mitotic spindle
Acronym: SpindleForceBalance
Leader: Nenad Pavin
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: KK.01.1.1.04.0057
Title (english): Inovative microscopy protocols for interdisciplinary research in biomedicine
Acronym: IPSted
Leader: Iva Marija Tolić
Jurisdiction: eu
ProjectNumber: KK.01.1.1.01.0004
Title (english): QuantiXLie Center of Excellence
Acronym: QuantiXLie
Leader: Hrvoje Buljan; Pavle Pandžić
Jurisdiction: eu
Funding stream: European Regional Development Fund - the Competitiveness and Cohesion Operational Programme
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0006349523000334
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Public noteCopyright © 2023 Biophysical Society. 2023 Biophysical Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Received 31 August 2022; Accepted 13 January 2023; Available online 18 January 2023; Version of Record 21 February 2023.
Created on2023-08-21 12:33:40