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Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes
Biophysical Journal, 122 (2023), 4; 632-645. https://doi.org/10.1016/j.bpj.2023.01.017
Ban, Ivana; Tomašić, Lucija; Trakala, Marianna; Tolić, Iva M.; Pavin, Nenad

Institucijski repozitorij: Repozitorij Prirodoslovno-matematičkog fakulteta

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Ban, I., Tomašić, L., Trakala, M., Tolić, I. M. i Pavin, N. (2023). Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes. Biophysical Journal, 122. (4), 632-645. doi: 10.1016/j.bpj.2023.01.017

Ban, Ivana, et al. "Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes." Biophysical Journal, vol. 122, br. 4, 2023, str. 632-645. https://doi.org/10.1016/j.bpj.2023.01.017

Ban, Ivana, Lucija Tomašić, Marianna Trakala, Iva M. Tolić i Nenad Pavin. "Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes." Biophysical Journal 122, br. 4 (2023): 632-645. https://doi.org/10.1016/j.bpj.2023.01.017

Ban, I., et al. (2023) 'Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes', Biophysical Journal, 122(4), str. 632-645. doi: 10.1016/j.bpj.2023.01.017

Ban I, Tomašić L, Trakala M, Tolić IM, Pavin N. Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes. Biophysical Journal [Internet]. 2023. [pristupljeno 16.05.2024.];122(4):632-645. doi: 10.1016/j.bpj.2023.01.017

I. Ban, L. Tomašić, M. Trakala, I. M. Tolić i N. Pavin, "Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes", Biophysical Journal, vol. 122, br. 4, str. 632-645, 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:276672. [Citirano: 16.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:217:276672
Podaci o radu
Naslov (engleski)Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes
AutorIvana Ban
AutorLucija Tomašić
AutorMarianna Trakala
AutorIva M. Tolić
AutorNenad Pavin
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Matematika
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Interdisciplinarne prirodne znanosti
Sažetak (engleski)
Most tumors have abnormal karyotypes, which arise from mistakes during mitotic division of healthy euploid cells and evolve through numerous complex mechanisms. In a recent mouse model with increased chromosome missegregation, chromosome gains dominate over losses both in pretumor and tumor tissues, whereas T-cell lymphomas are characterized by gains of chromosomes 14 and 15. However, the quantitative understanding of clonal selection leading to tumor karyotype evolution remains unknown. Here we show, by introducing a mathematical model based on a concept of a macro-karyotype, that tumor karyotypes can be explained by proliferation-driven evolution of aneuploid cells. In pretumor cells, increased apoptosis and slower proliferation of cells with monosomies lead to predominant chromosome gains over losses. Tumor karyotypes with gain of one chromosome can be explained by karyotype-dependent proliferation, whereas, for those with two chromosomes, an interplay with karyotype-dependent apoptosis is an additional possible pathway. Thus, evolution of tumor-specific karyotypes requires proliferative advantage of specific aneuploid karyotypes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiophysical Journal
Brojčani podacivol. 122, br. 4, str. 632-645
p-ISSN0006-3495
DOIhttps://doi.org/10.1016/j.bpj.2023.01.017
URN:NBNurn:nbn:hr:217:276672
Datum objave publikacije2023
ProjektŠifra: 8551580
Naziv (engleski): Molecular origins of aneuploidies in healthy and diseased human tissues
Kratica: ANEUPLOIDY
Voditelj: Iva Marija Tolić; Nenad Pavin
Pravna nadležnost: eu
Financijer: EC
ProjektŠifra: IP-2019-04-5967
Naziv (hrvatski): Ravnoteža sila i momenta sila u diobenom vretenu
Naziv (engleski): Balance of forces and torques in the mitotic spindle
Kratica: SpindleForceBalance
Voditelj: Nenad Pavin
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: KK.01.1.1.04.0057
Naziv (engleski): Inovative microscopy protocols for interdisciplinary research in biomedicine
Kratica: IPSted
Voditelj: Iva Marija Tolić
Pravna nadležnost: eu
Financijer: EC
ProjektŠifra: KK.01.1.1.01.0004
Naziv (engleski): QuantiXLie Center of Excellence
Kratica: QuantiXLie
Voditelj: Hrvoje Buljan; Pavle Pandžić
Pravna nadležnost: eu
Financijer: Croatian Government and European Union
Linija financiranja: European Regional Development Fund - the Competitiveness and Cohesion Operational Programme
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0006349523000334
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Javna napomenaCopyright © 2023 Biophysical Society. 2023 Biophysical Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Received 31 August 2022; Accepted 13 January 2023; Available online 18 January 2023; Version of Record 21 February 2023.
Datum i vrijeme pohrane2023-08-21 12:33:40