prikaz prve stranice dokumenta O-benziloksimi kao inhibitori butirilkolinesteraze
Embargo period 2025-09-18
master's thesis
O-benziloksimi kao inhibitori butirilkolinesteraze
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:020612
Laučan, Matea
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Laučan, M. (2023). O-benziloksimi kao inhibitori butirilkolinesteraze (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:020612

Laučan, Matea. "O-benziloksimi kao inhibitori butirilkolinesteraze." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:020612

Laučan, Matea. "O-benziloksimi kao inhibitori butirilkolinesteraze." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:020612

Laučan, M. (2023). 'O-benziloksimi kao inhibitori butirilkolinesteraze', Master's thesis, University of Zagreb, Faculty of Science, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:020612

Laučan M. O-benziloksimi kao inhibitori butirilkolinesteraze [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:020612

M. Laučan, "O-benziloksimi kao inhibitori butirilkolinesteraze", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:020612

Metadata
TitleO-benziloksimi kao inhibitori butirilkolinesteraze
Title (english)O-benzyloximes as butyrylcholinesterase inhibitors
AuthorMatea Laučan
MentorInes Primožič (mentor)
MentorAlma Ramić (komentor)
Committee memberInes Primožič (predsjednik povjerenstva)
Committee memberBiserka Prugovečki (član povjerenstva)
Committee memberAdriana Kenđel (član povjerenstva)
Committee memberNikola Cindro (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2023-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U okviru ovog rada klasičnim postupcima organske sinteze pripremljen je O-benzilni eter kinuklidin-3- on-oksima reakcijom hidroklorida kinuklidin-3-ona i O-benzilhidroksilamina bez dodatka organskih ili anorganskih baza. Kvaternizacijom kinuklidinskog atoma dušika u molekuli sintetiziranog Obenziloksima s metil-jodidom te odabranim, različito supstituiranim benzil-bromidima (metilna ili nitroskupina te atomi halogena u meta ili para položaju) pripremljena je serija od dvanaest novih kvaternih derivata. Odabrani spojevi imaju različite modifikacije u strukturi kako bi se mogli definirati strukturni parametri važni za postizanje poboljšane biološke aktivnosti spojeva u interakciji s kolinesterazama. Pripremljenim spojevima određeno je talište te je struktura potvrđena infracrvenom spektroskopijom, spektrometrijom masa te 1D i 2D spektroskopijom nuklearne magnetske rezonancije. Nadalje, svim pripremljenim spojevima određen je inhibitorni potencijal prema enzimu butirilkolinesterazi iz konjskog seruma (EC 3.1.1.8) korištenjem Ellmanove metode za kolorimetrijsko određivanje aktivnosti kolinesteraze.
Abstract (english)
In this work, O-benzyl ether of quinuclidin-3-one oxime was prepared by the reaction of hydrochloride salts of quinuclidin-3-one and O-benzylhydroxylamine without the addition of organic or inorganic bases. A series of twelve new quaternary derivatives were prepared by quaternization of the quinuclidine nitrogen atom with methyl iodide and selected, differently substituted benzyl bromides (methyl or nitro group and halogen atoms in the meta or para position). The selected compounds have different modifications in the structure to define the structural parameters important for achieving improved biological activity in the interaction with cholinesterases. The melting points of the prepared compounds were determined, and the structure was confirmed by infrared spectroscopy, mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Furthermore, the inhibitory potential of all prepared compounds toward the enzyme butyrylcholinesterase from horse serum (EC 3.1.1.8) was determined using the Ellman method for colorimetric determination of cholinesterase activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:020612
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-09-18
Terms of useLicence In copyright icon
Created on2023-09-25 12:57:23