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undergraduate thesis
Biljni sekundarni metaboliti kao model za razvoj lijekova
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:782817
Kufrin, Vida
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Kufrin, V. (2018). Biljni sekundarni metaboliti kao model za razvoj lijekova (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:782817

Kufrin, Vida. "Biljni sekundarni metaboliti kao model za razvoj lijekova." Undergraduate thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:782817

Kufrin, Vida. "Biljni sekundarni metaboliti kao model za razvoj lijekova." Undergraduate thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:782817

Kufrin, V. (2018). 'Biljni sekundarni metaboliti kao model za razvoj lijekova', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 29 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:782817

Kufrin V. Biljni sekundarni metaboliti kao model za razvoj lijekova [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 December 29] Available at: https://urn.nsk.hr/urn:nbn:hr:217:782817

V. Kufrin, "Biljni sekundarni metaboliti kao model za razvoj lijekova", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:782817

Metadata
TitleBiljni sekundarni metaboliti kao model za razvoj lijekova
Title (english)Plant secondary metabolites as a model for drug development
AuthorVida Kufrin
MentorIvana Šola (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2018, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Biljni sekundarni metaboliti su spojevi koji nisu nužni za rast i razvoj biljaka, ali im omogućavaju prilagodbu i preživljavanje u okolišu. Strukturna kompleksnost i raznolikost sekundarnih metabolita osigurala im je važnu ulogu u farmaceutskoj industriji. Ovi spojevi koriste se u liječenju različitih medicinskih stanja kao što su tumori, neurodegenerativne bolesti, parazitske bolesti s naglaskom na malariju, metabolički poremećaji te glaukom. Biljni sekundarni metaboliti mogu biti izravno korišteni kao lijekovi za kliničku upotrebu, kao npr. galantamin, vinblastin i kinin. Sintetska optimizacija često je potrebna kako bi se povećala dostupnost samog spoja, u tom slučaju koriste se kao prototip za sintezu velikog broja strukturnih analoga koji mogu biti korišteni u razvoju lijekova. Dobri primjeri ovakve uporabe su paklitaksel, nitizinon i oseltamivir fosfat. Također, mogu biti korišteni i kao farmakološki i biokemijski alati u istraživanju mehanizama koji dovode do bolesti. Neki od spojeva korišteni u tu svrhu su genistein, kvercetin i forskolin.
Abstract (english)
Plant secondary metabolites are compounds not essential for plant growth and development, but are useful for adjustment and survival of plants in environment. Secondary metabolites structural complexity and diversity has ensured them an important role in pharmaceutical industry. Plant secondary metabolites are used for treatment of various medical conditions such as cancer, neurodegenerative diseases, parasitic diseases with emphasis on malaria, metabolic disorders and glaucoma. These compounds can be used directly as drugs in clinical use, like galantamine, vinblastine and quinine. Synthetic optimization is often required to increase bioavailability, in that case plant secondary metabolites serve as prototypes for the synthesis of high number of structural analogs that can be used in drug development. Good examples for such use are paclitaxel, nitisinone and oseltamivir phospate. Further, plant secondary metabolites can also serve as pharmacological and biochemical probes to help explain the mechanisms underlying human diseases. Some of the compounds used for this purpose are genistein, quercetin and forskolin.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:782817
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-10-01 10:42:26