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Scientific paper - Original scientific paper
Swinging a sword : how microtubules search for their targets
Systems and Synthetic Biology, 8 (2014), 3; 179-186. https://doi.org/10.1007/s11693-014-9134-x
Pavin, Nenad; Tolić‑Nørrelykke, Iva M.

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Pavin, N. & Tolić‑Nørrelykke, I. M. (2014). Swinging a sword : how microtubules search for their targets. Systems and Synthetic Biology, 8. (3), 179-186. doi: 10.1007/s11693-014-9134-x

Pavin, Nenad and Iva M. Tolić‑Nørrelykke. "Swinging a sword : how microtubules search for their targets." Systems and Synthetic Biology, vol. 8, no. 3, 2014, pp. 179-186. https://doi.org/10.1007/s11693-014-9134-x

Pavin, Nenad and Iva M. Tolić‑Nørrelykke. "Swinging a sword : how microtubules search for their targets." Systems and Synthetic Biology 8, no. 3 (2014): 179-186. https://doi.org/10.1007/s11693-014-9134-x

Pavin, N. and Tolić‑Nørrelykke, I. M. (2014) 'Swinging a sword : how microtubules search for their targets', Systems and Synthetic Biology, 8(3), pp. 179-186. doi: 10.1007/s11693-014-9134-x

Pavin N, Tolić‑Nørrelykke IM. Swinging a sword : how microtubules search for their targets. Systems and Synthetic Biology [Internet]. 2014 [cited 2024 December 21];8(3):179-186. doi: 10.1007/s11693-014-9134-x

N. Pavin and I. M. Tolić‑Nørrelykke, "Swinging a sword : how microtubules search for their targets", Systems and Synthetic Biology, vol. 8, no. 3, pp. 179-186, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:436716. [Accessed: 21 December 2024]

Metadata
Title (english)Swinging a sword : how microtubules search for their targets
AuthorNenad Pavin
AuthorIva M. Tolić‑Nørrelykke
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract (english)
The cell interior is in constant movement, which is to a large extent determined by microtubules, thin and long filaments that permeate the cytoplasm. To move large objects, microtubules need to connect them to the site of their destination. For example, during cell division, microtubules connect chromosomes with the spindle poles via kinetochores, protein complexes on the chromosomes. A general question is how microtubules, while being bound to one structure, find the target that needs to be connected to this structure. Here we review the mechanisms of how microtubules search for kinetochores, with emphasis on the recently discovered microtubule feature to explore space by pivoting around the spindle pole. In addition to accelerating the search for kinetochores, pivoting helps the microtubules to search for cortical anchors, as well as to self-organize into parallel arrays and asters to target specific regions of the cell. Thus, microtubule pivoting constitutes a mechanism by which they locate targets in different cellular contexts.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleSystems and Synthetic Biology
Numberingvol. 8, no. 3, pp. 179-186
p-ISSN1872-5325
e-ISSN1872-5333
DOIhttps://doi.org/10.1007/s11693-014-9134-x
URN:NBNurn:nbn:hr:217:436716
Publication2014
Document URLhttps://link.springer.com/article/10.1007/s11693-014-9134-x
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Public note© The Author(s) 2014. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Received: 7 December 2013. Accepted: 4 February 2014. Published online: 16 February 2014.
Created on2019-11-29 14:51:29