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master's thesis
Dokazivanje varijantnih translokacija Ph kromosoma metodom interfazne fluorescencijske hibridizacije in situ (FISH)
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:078728
Jurić, Magdalena
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Jurić, M. (2013). Dokazivanje varijantnih translokacija Ph kromosoma metodom interfazne fluorescencijske hibridizacije in situ (FISH) (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:078728

Jurić, Magdalena. "Dokazivanje varijantnih translokacija Ph kromosoma metodom interfazne fluorescencijske hibridizacije in situ (FISH)." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:078728

Jurić, Magdalena. "Dokazivanje varijantnih translokacija Ph kromosoma metodom interfazne fluorescencijske hibridizacije in situ (FISH)." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:078728

Jurić, M. (2013). 'Dokazivanje varijantnih translokacija Ph kromosoma metodom interfazne fluorescencijske hibridizacije in situ (FISH)', Master's thesis, University of Zagreb, Faculty of Science, accessed 03 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:078728

Jurić M. Dokazivanje varijantnih translokacija Ph kromosoma metodom interfazne fluorescencijske hibridizacije in situ (FISH) [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 May 03] Available at: https://urn.nsk.hr/urn:nbn:hr:217:078728

M. Jurić, "Dokazivanje varijantnih translokacija Ph kromosoma metodom interfazne fluorescencijske hibridizacije in situ (FISH)", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:078728

Metadata
TitleDokazivanje varijantnih translokacija Ph kromosoma metodom interfazne fluorescencijske hibridizacije in situ (FISH)
Title (english)Detection of variant Ph chromosome translocations by interphasic fluorescence hybridization in situ (FISH)
AuthorMagdalena Jurić
MentorSanja Davidović-Mrsić (mentor)
MentorInga Marijanović (mentor)
Committee memberInga Marijanović (predsjednik povjerenstva)
Committee memberSanja Davidović-Mrsić (član povjerenstva)
Committee memberTatjana Bakran-Petricioli (član povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013-07-08, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Kronična mijeloična leukemija (KML) je mijeloproliferativni poremećaj, karakteriziran prisutnošću Philadelphia (Ph) kromosoma, koji je rezultat recipročne translokacije između kromosoma 9 i 22, t(9;22)(q34;q11). Molekularna posljedica ove translokacije je konstitutivno aktivni tirozin kinazni protein BCR-ABL1, koji uzrokuje KML fosforilacijom brojnih nizvodnih proteina uključenih u stanični rast i apoptozu. Smatra se da velika većina pacijenata (95%) s KML-om pokazuje prisutnost klasične translokacije t(9;22)(q34;q11), te da su varijantne translokacije prisutne u 5-10% pacijenata s KML-om. U tim slučajevima, u translokaciju su uključeni dodatni jedan ili više kromosoma, uz kromosome 9 i 22. Cilj rada je dokazati prisutnost varijantnih translokacija Ph kromosoma pomoću interfazne fluorescencijske hibridizacije in situ (I-FISH) u pacijenata s kroničnom mijeloičnom leukemijom pri dijagnozi, korištenjem probe LSI BCR/ABL Dual Color, Dual Fusion.
Abstract (english)
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the presence of the Philadelphia (Ph) chromosome, which is the result of the reciprocal translocation between chromosome 9 i 22, t(9;22)(q34;q11). The molecular consequence of this translocation is constitutively active protein tyrosine kinase BCR-ABL1, which causes CML by phosphorylating numerous downstream proteins involved in cell growth and apoptosis. It is considered that the vast majority of patients with CML show classical t(9;22)(q34q11) translocation and that in 5-10% CML cases variant Ph translokations are present. In these cases, one or more additional chromosomes are added to 9 and 22 chromosomes in translocation. The aim of this paper is to detect variant Ph chromosome translocations by interphasic fluorescence hybridization in situ (I-FISH) in patients with chonic myeloid leukemia at diagnosis, using LSI BCR/ABL Dual Color, Dual Fusion probe.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:078728
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
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Created on2017-04-27 08:50:30