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master's thesis
Poboljšanje topljivosti loratadina uslijed kompleksiranja s odabranim ciklodekstrinima
Zagreb: University of Zagreb, Faculty of Science, 2021. urn:nbn:hr:217:015578
Mamić, Nina
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Mamić, N. (2021). Poboljšanje topljivosti loratadina uslijed kompleksiranja s odabranim ciklodekstrinima (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:015578

Mamić, Nina. "Poboljšanje topljivosti loratadina uslijed kompleksiranja s odabranim ciklodekstrinima." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:015578

Mamić, Nina. "Poboljšanje topljivosti loratadina uslijed kompleksiranja s odabranim ciklodekstrinima." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:015578

Mamić, N. (2021). 'Poboljšanje topljivosti loratadina uslijed kompleksiranja s odabranim ciklodekstrinima', Master's thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:015578

Mamić N. Poboljšanje topljivosti loratadina uslijed kompleksiranja s odabranim ciklodekstrinima [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2021 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:015578

N. Mamić, "Poboljšanje topljivosti loratadina uslijed kompleksiranja s odabranim ciklodekstrinima", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:217:015578

Metadata
TitlePoboljšanje topljivosti loratadina uslijed kompleksiranja s odabranim ciklodekstrinima
Title (english)Improvement of loratadine solubility by complexation with cyclodextrins
AuthorNina Mamić
MentorNives Galić (mentor)
Committee memberNives Galić (predsjednik povjerenstva)
Committee memberInes Primožič (član povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberAdriana Kenđel (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2021-01-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Loratadin (LOR) je antihistaminik druge generacije koji prema biofarmaceutskom sustavu klasifikacije spada u skupinu slabo topljivih djelatnih tvari (skupina Ⅱ). Međutim, utvrđeno je da mu se topljivost povećava ukoliko je u kompleksu s ciklodekstrinom. U ovom radu istražen je utjecaj β-ciklodekstrina i njegovog derivata hidroksipropil-β-ciklodekstrina na topljivost loratadina u vodi i biorelevantnim medijima (pH 4,5 i 6,8). Loratadin je kvantitativno određen tekućinskom kromatografijom visoke djelotvornosti i UV/Vis spektrofotometrijom. Kompleksi u čvrstom stanju pripremljeni su mljevenjem u visokoenergetskim mlinovima uz dodatak male količine otapala, kao i bez otapala. Za potvrdu nastanka kompleksa korištena je infracrvena spektroskopija tehnikom prigušene totalne refleksije i u transmisijskom načinu snimanja.
Abstract (english)
Loratadine is a second-generation antihistamine that is categorized in the Biopharmaceutics Classification System as a poorly water-soluble drug (BSC II class). However, studies have shown that its solubility increases with the addition of cyclodextrin. In this thesis, the effect of β-cyclodextrin and hydroxypropyl-β-cyclodextrin on the solubility of loratadine in water and biorelevant media (pH 4.5 and 6.8), was studied. High-performance liquid chromatography and UV/Vis spectrophotometry were used for the quantitative determination of loratadine. Solid loratadine-cyclodextrin inclusion complexes were prepared by grinding in high energy vibrational mills with the addition of small catalytic amounts of solvent and also without solvent. Infrared spectroscopy was used to confirm the formation of the complexes, using the technique of attenuated total reflection and the transmission mode.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:015578
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-01-29
Terms of useLicence In copyright icon
Created on2021-03-08 10:57:24