This thesis describes research of total synthesis of marinoazepinones A and B as well as the synthesis of their precursors. In the first step, the pyrrole nitrogen is protected and then regioselectively brominated at the C–3 position. The brominated protected pyrrole was converted by Miyaura borylation reaction into boronate. In the next step, the conditions for the Suzuki–Miyaura reaction of the obtained boronate with 2–iodoaniline were studied to prepare an adduct of protected pyrrole and 2–iodoaniline. After deprotecting the pyrrole ring of the adduct, selective bromination was performed at the C–2 position of the pyrrole ring, and all three free nitrogens on the brominated adduct were protected. Obtained bromide was used to investigate transmethalation using n–butyllithium or isopropylmagnesium chloride and for the addition to the suitable compounds in order to obtain a ketone product as a precursor for further cyclization. Marinoazepinones A and B as target compounds have not been synthesized, but valuable precursors have been prepared which will contribute to further research of their total synthesis.