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master's thesis
Sinteza nekih heterocikličkih spojeva s kumarinskom jezgrom
Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2012. urn:nbn:hr:109:256887
Groznica, Sanda
Josip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Department of Applied Chemistry and Ecology
Sub-department of Chemistry and Ecology

Institutional repository: Repository of the Faculty of Food Technology Osijek

Cite this document

Groznica, S. (2012). Sinteza nekih heterocikličkih spojeva s kumarinskom jezgrom (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY. Retrieved from https://urn.nsk.hr/urn:nbn:hr:109:256887

Groznica, Sanda. "Sinteza nekih heterocikličkih spojeva s kumarinskom jezgrom." Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2012. https://urn.nsk.hr/urn:nbn:hr:109:256887

Groznica, Sanda. "Sinteza nekih heterocikličkih spojeva s kumarinskom jezgrom." Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2012. https://urn.nsk.hr/urn:nbn:hr:109:256887

Groznica, S. (2012). 'Sinteza nekih heterocikličkih spojeva s kumarinskom jezgrom', Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:109:256887

Groznica S. Sinteza nekih heterocikličkih spojeva s kumarinskom jezgrom [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY; 2012 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:109:256887

S. Groznica, "Sinteza nekih heterocikličkih spojeva s kumarinskom jezgrom", Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, Osijek, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:109:256887

Metadata
TitleSinteza nekih heterocikličkih spojeva s kumarinskom jezgrom
Title (english)The synthesis of some heterocyclic compounds with coumarinic core
AuthorSanda Groznica
MentorMilan Čačić (mentor)
Committee memberIvica Strelec
Committee memberMilan Čačić
Committee memberJurislav Babić
Committee memberDaniela Čačić Kenjerić
GranterJosip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
(Department of Applied Chemistry and Ecology)
(Sub-department of Chemistry and Ecology)
Osijek
Defense date and country2012-05-31, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Engineering
Abstract
Kumarin (2H-kromen-2-on) i njegovi derivati predstavljaju najaktivniju grupu heterocikličkih organskih spojeva koji se mogu naći u biljkama, mikroorganizmima i životinjama, te posjeduju i širok spektar biološke aktivnosti. Prirodni i sintetski kumarini posjeduju antibakterijska, antikoagulacijska, antimikrobna, fungicidna i dr. djelovanja. U ovom diplomskom radu provedena je sinteza nekih heterocikličkih spojeva s kumarinskom jezgrom. (7-hidroksi-2-okso-2H-kromen-4-il) octena kiselina sintetizirana je iz limunske kiseline i rezorcinola u prisutnosti koncentrirane sumporne kiseline. Reakcijom hidrazin hidrata s derivatima karboksilnih kiselina nastaju hidrazidi karboksilnih kiselina, te je pronađeno da i hidrazidi na bazi kumarina imaju višestruku primjenu. Reakcija je praćena tankoslojnom kromatografijom, a nastali spojevi su pročišćeni prekristalizacijom i određene su im točke tališta. Struktura novosintetiziranih spojeva potvrđena je elementarnom mikroanalizom, te 1H-NMR i IR spektrometrijom.
Abstract (english)
Coumarin (2H-chromene-2-ones) and his derivatives represent the most active group of heterocyclic organic compounds which can be found in plants, microorganisms and animals and have wide spectrum of biological activity. Natural and synthetic coumarins possess antibacterial, anticoagulant, antimicrobial, fungicidal and other activity. In this graduate work we performed synthesis of some heterocyclic compounds with coumarinic core. (7-hydroxy-2-oxo-2H-chromen-4-yl) acetic acid was synthesized from citric acid and resorcinol in the presence of concentrated sulfuric acid. Reaction between hydrazine hydrate and carboxylic acid derivatives gave hydrazides carboxylic acids, with multiple applications. The reaction was followed with thin–layer chromatography, compounds were purified by recrystallization and melting points were measured. Structure of newly synthesized compounds is confirmed by elemental microanalysis and 1H-NMR and IR spectrometry.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:109:256887
Study programmeTitle: Food Technology and Process Engineering
Study programme type: university
Study level: graduate
Academic / professional title: diplomirani inženjer prehrambene tehnologije i procesnog inženjerstva (diplomirani inženjer prehrambene tehnologije i procesnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2015-11-04 12:17:51