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Scientific paper - Review paper
Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer
International Journal of Molecular Sciences, 22 (2021), 11; 5681. https://doi.org/10.3390/ijms22115681
Novak Kujundžić, Renata; Prpić, Marin; Đaković, Nikola; Dabelić, Nina; Tomljanović, Marko; Mojzeš, Anamarija; Fröbe, Ana; Trošelj, Koraljka Gall

Institutional repository: University of Zagreb School of Dental Medicine Repository

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Novak Kujundžić, R., Prpić, M., Đaković, N., Dabelić, N., Tomljanović, M., Mojzeš, A. ... Trošelj, K. G. (2021). Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer. International Journal of Molecular Sciences, 22. (11). doi: 10.3390/ijms22115681

Novak Kujundžić, Renata, et al. "Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer." International Journal of Molecular Sciences, vol. 22, no. 11, 2021. https://doi.org/10.3390/ijms22115681

Novak Kujundžić, Renata, Marin Prpić, Nikola Đaković, Nina Dabelić, Marko Tomljanović, Anamarija Mojzeš, Ana Fröbe and Koraljka Gall Trošelj. "Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer." International Journal of Molecular Sciences 22, no. 11 (2021). https://doi.org/10.3390/ijms22115681

Novak Kujundžić, R., et al. (2021) 'Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer', International Journal of Molecular Sciences, 22(11). doi: 10.3390/ijms22115681

Novak Kujundžić R, Prpić M, Đaković N, Dabelić N, Tomljanović M, Mojzeš A, and sur.. Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer. International Journal of Molecular Sciences [Internet]. 2021 May 26 [cited 2024 April 20];22(11). doi: 10.3390/ijms22115681

R. Novak Kujundžić, et al., "Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer", International Journal of Molecular Sciences, vol. 22, no. 11, May 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:274723. [Accessed: 20 April 2024]

Metadata
Title (english)Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer
AuthorRenata Novak Kujundžić
AuthorMarin Prpić
AuthorNikola Đaković
AuthorNina Dabelić
AuthorMarko Tomljanović
AuthorAnamarija Mojzeš
AuthorAna Fröbe
AuthorKoraljka Gall Trošelj
Author's institutionRuđer Bošković Institute
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation of nicotinamide (NAM) into methyl nicotinamide (MNAM), which is either excreted or further metabolized to N1-methyl-2-pyridone-5-carboxamide (2-PY) and H2O2. Enzymatic activity of NNMT is important for the prevention of NAM-mediated inhibition of NAD+-consuming enzymes poly–adenosine -diphosphate (ADP), ribose polymerases (PARPs), and sirtuins (SIRTs). Inappropriately high expression and activity of NNMT, commonly present in various types of cancer, has the potential to disrupt NAD+ homeostasis and cellular methylation potential. Largely overlooked, in the context of cancer, is the inhibitory effect of 2-PY on PARP-1 activity, which abrogates NNMT’s positive effect on cellular NAD+ flux by stalling liberation of NAM and reducing NAD+ synthesis in the salvage pathway. This review describes, and discusses, the mechanisms by which NNMT promotes NAD+ depletion and epigenetic reprogramming, leading to the development of metabolic plasticity, evasion of a major tumor suppressive process of cellular senescence, and acquisition of stem cell properties. All these phenomena are related to therapy resistance and worse clinical outcomes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 22, no. 11, 5681
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms22115681
URN:NBNurn:nbn:hr:127:274723
Publication2021-05-26
Document URLhttps://www.mdpi.com/1422-0067/22/11/5681
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-10 10:23:43