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Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer
International Journal of Molecular Sciences, 22 (2021), 11; 5681. https://doi.org/10.3390/ijms22115681
Novak Kujundžić, Renata; Prpić, Marin; Đaković, Nikola; Dabelić, Nina; Tomljanović, Marko; Mojzeš, Anamarija; Fröbe, Ana; Trošelj, Koraljka Gall

Institucijski repozitorij: Repozitorij stomatološkog fakulteta u Zagrebu

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Novak Kujundžić, R., Prpić, M., Đaković, N., Dabelić, N., Tomljanović, M., Mojzeš, A. ... Trošelj, K. G. (2021). Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer. International Journal of Molecular Sciences, 22. (11). doi: 10.3390/ijms22115681

Novak Kujundžić, Renata, et al. "Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer." International Journal of Molecular Sciences, vol. 22, br. 11, 2021. https://doi.org/10.3390/ijms22115681

Novak Kujundžić, Renata, Marin Prpić, Nikola Đaković, Nina Dabelić, Marko Tomljanović, Anamarija Mojzeš, Ana Fröbe i Koraljka Gall Trošelj. "Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer." International Journal of Molecular Sciences 22, br. 11 (2021). https://doi.org/10.3390/ijms22115681

Novak Kujundžić, R., et al. (2021) 'Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer', International Journal of Molecular Sciences, 22(11). doi: 10.3390/ijms22115681

Novak Kujundžić R, Prpić M, Đaković N, Dabelić N, Tomljanović M, Mojzeš A, i sur.. Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer. International Journal of Molecular Sciences [Internet]. 26.05.2021. [pristupljeno 28.11.2024.];22(11). doi: 10.3390/ijms22115681

R. Novak Kujundžić, et al., "Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer", International Journal of Molecular Sciences, vol. 22, br. 11, Svibanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:274723. [Citirano: 28.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:274723
Podaci o radu
Naslov (engleski)Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer
AutorRenata Novak Kujundžić
AutorMarin Prpić
AutorNikola Đaković
AutorNina Dabelić
AutorMarko Tomljanović
AutorAnamarija Mojzeš
AutorAna Fröbe
AutorKoraljka Gall Trošelj
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Sažetak (engleski)
The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation of nicotinamide (NAM) into methyl nicotinamide (MNAM), which is either excreted or further metabolized to N1-methyl-2-pyridone-5-carboxamide (2-PY) and H2O2. Enzymatic activity of NNMT is important for the prevention of NAM-mediated inhibition of NAD+-consuming enzymes poly–adenosine -diphosphate (ADP), ribose polymerases (PARPs), and sirtuins (SIRTs). Inappropriately high expression and activity of NNMT, commonly present in various types of cancer, has the potential to disrupt NAD+ homeostasis and cellular methylation potential. Largely overlooked, in the context of cancer, is the inhibitory effect of 2-PY on PARP-1 activity, which abrogates NNMT’s positive effect on cellular NAD+ flux by stalling liberation of NAM and reducing NAD+ synthesis in the salvage pathway. This review describes, and discusses, the mechanisms by which NNMT promotes NAD+ depletion and epigenetic reprogramming, leading to the development of metabolic plasticity, evasion of a major tumor suppressive process of cellular senescence, and acquisition of stem cell properties. All these phenomena are related to therapy resistance and worse clinical outcomes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 22, br. 11, 5681
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms22115681
URN:NBNurn:nbn:hr:127:274723
Datum objave publikacije2021-05-26
URL dokumentahttps://www.mdpi.com/1422-0067/22/11/5681
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-11-10 10:23:43