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Scientific paper - Original scientific paper
Detection of Leachable Components from Conventional and Dental Bulk-Fill Resin Composites (High and Low Viscosity) Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method
Polymers, 15 (2023), 3; 627. https://doi.org/10.3390/polym15030627
Barišić, Matea Lapaš; Sarajlija, Hrvoje; Klarić, Eva; Knežević, Alena; Sabol, Ivan; Pandurić, Vlatko

Institutional repository: University of Zagreb School of Dental Medicine Repository

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Barišić, M. L., Sarajlija, H., Klarić, E., Knežević, A., Sabol, I. & Pandurić, V. (2023). Detection of Leachable Components from Conventional and Dental Bulk-Fill Resin Composites (High and Low Viscosity) Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method. Polymers, 15. (3). doi: 10.3390/polym15030627

Barišić, Matea Lapaš, et al. "Detection of Leachable Components from Conventional and Dental Bulk-Fill Resin Composites (High and Low Viscosity) Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method." Polymers, vol. 15, no. 3, 2023. https://doi.org/10.3390/polym15030627

Barišić, Matea Lapaš, Hrvoje Sarajlija, Eva Klarić, Alena Knežević, Ivan Sabol and Vlatko Pandurić. "Detection of Leachable Components from Conventional and Dental Bulk-Fill Resin Composites (High and Low Viscosity) Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method." Polymers 15, no. 3 (2023). https://doi.org/10.3390/polym15030627

Barišić, M. L., et al. (2023) 'Detection of Leachable Components from Conventional and Dental Bulk-Fill Resin Composites (High and Low Viscosity) Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method', Polymers, 15(3). doi: 10.3390/polym15030627

Barišić ML, Sarajlija H, Klarić E, Knežević A, Sabol I, Pandurić V. Detection of Leachable Components from Conventional and Dental Bulk-Fill Resin Composites (High and Low Viscosity) Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method. Polymers [Internet]. 2023 January 25 [cited 2025 January 13];15(3). doi: 10.3390/polym15030627

M. L. Barišić, H. Sarajlija, E. Klarić, A. Knežević, I. Sabol and V. Pandurić, "Detection of Leachable Components from Conventional and Dental Bulk-Fill Resin Composites (High and Low Viscosity) Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method", Polymers, vol. 15, no. 3, January 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:443043. [Accessed: 13 January 2025]

Metadata
Title (english)Detection of Leachable Components from Conventional and Dental Bulk-Fill Resin Composites (High and Low Viscosity) Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method
AuthorMatea Lapaš Barišić
AuthorHrvoje Sarajlija
AuthorEva Klarić
AuthorAlena Knežević
AuthorIvan Sabol
AuthorVlatko Pandurić
Author's institutionRuđer Bošković Institute
Author's institution(Zagreb University Hispital Center)
Author's institutionUniversity of Zagreb
School of Dental Medicine
(Department of Endodontics and Restorative Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Endodonics and Restorative Dentistry
Abstract (english)
The aim of this study was to investigate leachable components (monomers) in high and low viscosity dental bulk-fill resin composites and conventional resin composite materials after polymerization. Six bulk-fill and six conventional dental resin composite materials were used in this study. The samples of each material (three sets of triplicates) were cured for 20 s with irradiance of 1200 mW/cm2 with a LED curing unit and immersed in a 75% ethanol solution at 37 °C. The eluates from each triplicate set were analyzed after 24 h, 7 days or 28 days using liquid chromatography coupled with triple quadrupole tandem mass spectrometry (LC-MS/MS). Detectable amounts of 2-Hydroxyethyl methacrylate (HEMA) were found in both Gradia materials and the amount observed across different time points was statistically different (p ˂ 0.05), with the amount in solution increasing for Gradia and decreasing for Gradia Direct flo. Bisphenol A diglycidildimethacrylate (BIS GMA) was found in Filtek and Tetric materials. Triethylene glycol dimethacrylate (TEGDMA) was detected in all materials. On the other hand, there were no statistically significant differences in the amounts of TEGDMA detected across different time points in either of the tested materials. Monomers HEMA, TEGDMA, 4-dimethylaminobenzoic acid ethyl ester (DMA BEE) and BIS GMA in bulk-fill and conventional composites (high and low viscosity) can be eluted after polymerization. The good selection of composite material and proper handling, the following of the manufacturer’s instructions for polymerization and the use of finishing and polishing procedures may reduce the elution of the unpolymerized monomers> responsible for the possible allergic and genotoxic potential of dental resin composites.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePolymers
Numberingvol. 15, no. 3, 627
e-ISSN2073-4360
DOIhttps://doi.org/10.3390/polym15030627
URN:NBNurn:nbn:hr:127:443043
Publication2023-01-25
Document URLhttps://www.mdpi.com/2073-4360/15/3/627
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-03-17 10:13:46