prikaz prve stranice dokumenta Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives
  Download
PDF 733.37 KB
Scientific paper - Original scientific paper
Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives
Journal of Xenobiotics, 14 (2024), 1; 154-165. https://doi.org/10.3390/jox14010009
Tadin, Antonija; Stazić, Vinka; Galić, Nada; Želježić, Davor

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Tadin, A., Stazić, V., Galić, N. & Želježić, D. (2024). Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives. Journal of Xenobiotics, 14. (1), 154-165. doi: 10.3390/jox14010009

Tadin, Antonija, et al. "Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives." Journal of Xenobiotics, vol. 14, no. 1, 2024, pp. 154-165. https://doi.org/10.3390/jox14010009

Tadin, Antonija, Vinka Stazić, Nada Galić and Davor Želježić. "Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives." Journal of Xenobiotics 14, no. 1 (2024): 154-165. https://doi.org/10.3390/jox14010009

Tadin, A., et al. (2024) 'Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives', Journal of Xenobiotics, 14(1), pp. 154-165. doi: 10.3390/jox14010009

Tadin A, Stazić V, Galić N, Želježić D. Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives. Journal of Xenobiotics [Internet]. 2024 January 12 [cited 2024 November 26];14(1):154-165. doi: 10.3390/jox14010009

A. Tadin, V. Stazić, N. Galić and D. Želježić, "Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives", Journal of Xenobiotics, vol. 14, no. 1, pp. 154-165, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:581183. [Accessed: 26 November 2024]

Metadata
Title (english)Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives
AuthorAntonija Tadin
AuthorVinka Stazić
AuthorNada Galić
MBZ: 192110
AuthorDavor Želježić
Author's institutionInstitute for Medical Research and Occupational Health
Author's institution(Zagreb University Hispital Center)
Author's institutionUniversity of Split
School of Medicine
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Aims/Objectives: The aim of this cross-sectional observational study was to investigate cytogenetic damage to the buccal mucosa in non-smokers and consumers of traditional combustible tobacco products and non-combustible alternatives. Methods: A total of 160 participants were divided into four groups according to the type of product used, including non-smokers, users of conventional combustible tobacco (cigarettes), heated tobacco, and electronic, tobacco-free vapor products (e-cigarettes). Buccal mucosa samples were analyzed using the micronucleus cytome assay to assess cytotoxic and genotoxic damage. Results: E-cigarette users showed significantly higher values for all tested parameters in the micronucleus test compared to non-smokers (p < 0.05). Similarly, users of tobacco heating products showed an increase in all parameters (p < 0.05), with the exception of the number of cells with micronuclei. Conventional cigarette smokers showed a notable increase in the number of binucleated cells and cells with karyorrhexis and karyolysis (p ≤ 0.05). When assessing the differences between users of traditional combustible tobacco products and non-combustible alternatives, these did not appear to be significant, except for e-cigarette users, who had significantly more cells with condensed chromatin (p ≤ 0.001), while users of tobacco heating products had more pyknotic cells (p ≤ 0.001). Conclusion: The results of this study underscore the heightened occurrence of cytotoxic and genotoxic damage in users of both conventional combustible tobacco products and non-combustible alternatives compared to non-smokers, emphasizing the detrimental impact of these products on the oral mucosa.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Xenobiotics
Numberingvol. 14, no. 1, pp. 154-165
e-ISSN2039-4713
DOIhttps://doi.org/10.3390/jox14010009
URN:NBNurn:nbn:hr:127:581183
Publication2024-01-12
Document URLhttps://www.mdpi.com/2039-4713/14/1/9
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-07-01 07:44:48