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Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives
Journal of Xenobiotics, 14 (2024), 1; 154-165. https://doi.org/10.3390/jox14010009
Tadin, Antonija; Stazić, Vinka; Galić, Nada; Želježić, Davor

Institucijski repozitorij: Repozitorij stomatološkog fakulteta u Zagrebu

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Tadin, A., Stazić, V., Galić, N. i Želježić, D. (2024). Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives. Journal of Xenobiotics, 14. (1), 154-165. doi: 10.3390/jox14010009

Tadin, Antonija, et al. "Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives." Journal of Xenobiotics, vol. 14, br. 1, 2024, str. 154-165. https://doi.org/10.3390/jox14010009

Tadin, Antonija, Vinka Stazić, Nada Galić i Davor Želježić. "Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives." Journal of Xenobiotics 14, br. 1 (2024): 154-165. https://doi.org/10.3390/jox14010009

Tadin, A., et al. (2024) 'Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives', Journal of Xenobiotics, 14(1), str. 154-165. doi: 10.3390/jox14010009

Tadin A, Stazić V, Galić N, Želježić D. Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives. Journal of Xenobiotics [Internet]. 12.01.2024. [pristupljeno 09.11.2024.];14(1):154-165. doi: 10.3390/jox14010009

A. Tadin, V. Stazić, N. Galić i D. Želježić, "Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives", Journal of Xenobiotics, vol. 14, br. 1, str. 154-165, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:581183. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:581183
Podaci o radu
Naslov (engleski)Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives
AutorAntonija Tadin
AutorVinka Stazić
AutorNada Galić
MBZ: 192110
AutorDavor Želježić
Autorova ustanovaInstitut za medicinska istraživanja i medicinu rada
Autorova ustanova(Klinički bolnički centar Zagreb)
Autorova ustanovaSveučilište u Splitu
Medicinski fakultet
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Sažetak (engleski)
Aims/Objectives: The aim of this cross-sectional observational study was to investigate cytogenetic damage to the buccal mucosa in non-smokers and consumers of traditional combustible tobacco products and non-combustible alternatives. Methods: A total of 160 participants were divided into four groups according to the type of product used, including non-smokers, users of conventional combustible tobacco (cigarettes), heated tobacco, and electronic, tobacco-free vapor products (e-cigarettes). Buccal mucosa samples were analyzed using the micronucleus cytome assay to assess cytotoxic and genotoxic damage. Results: E-cigarette users showed significantly higher values for all tested parameters in the micronucleus test compared to non-smokers (p < 0.05). Similarly, users of tobacco heating products showed an increase in all parameters (p < 0.05), with the exception of the number of cells with micronuclei. Conventional cigarette smokers showed a notable increase in the number of binucleated cells and cells with karyorrhexis and karyolysis (p ≤ 0.05). When assessing the differences between users of traditional combustible tobacco products and non-combustible alternatives, these did not appear to be significant, except for e-cigarette users, who had significantly more cells with condensed chromatin (p ≤ 0.001), while users of tobacco heating products had more pyknotic cells (p ≤ 0.001). Conclusion: The results of this study underscore the heightened occurrence of cytotoxic and genotoxic damage in users of both conventional combustible tobacco products and non-combustible alternatives compared to non-smokers, emphasizing the detrimental impact of these products on the oral mucosa.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Xenobiotics
Brojčani podacivol. 14, br. 1, str. 154-165
e-ISSN2039-4713
DOIhttps://doi.org/10.3390/jox14010009
URN:NBNurn:nbn:hr:127:581183
Datum objave publikacije2024-01-12
URL dokumentahttps://www.mdpi.com/2039-4713/14/1/9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-07-01 07:44:48