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Scientific paper - Original scientific paper
Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease
Journal of Pediatric Gastroenterology and Nutrition, 70 (2020), 4; 497-502. https://doi.org/10.1097/MPG.0000000000002611
Sila, Sara; Jelić, Marko; Trivić, Ivana; Tambić Andrašević, Arjana; Hojsak, Iva; Kolaček, Sanja

Institutional repository: University of Zagreb School of Dental Medicine Repository

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Sila, S., Jelić, M., Trivić, I., Tambić Andrašević, A., Hojsak, I. & Kolaček, S. (2020). Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition, 70. (4), 497-502. doi: 10.1097/MPG.0000000000002611

Sila, Sara, et al. "Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 70, no. 4, 2020, pp. 497-502. https://doi.org/10.1097/MPG.0000000000002611

Sila, Sara, Marko Jelić, Ivana Trivić, Arjana Tambić Andrašević, Iva Hojsak and Sanja Kolaček. "Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease." Journal of Pediatric Gastroenterology and Nutrition 70, no. 4 (2020): 497-502. https://doi.org/10.1097/MPG.0000000000002611

Sila, S., et al. (2020) 'Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease', Journal of Pediatric Gastroenterology and Nutrition, 70(4), pp. 497-502. doi: 10.1097/MPG.0000000000002611

Sila S, Jelić M, Trivić I, Tambić Andrašević A, Hojsak I, Kolaček S. Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition [Internet]. 2020 April [cited 2025 January 01];70(4):497-502. doi: 10.1097/MPG.0000000000002611

S. Sila, M. Jelić, I. Trivić, A. Tambić Andrašević, I. Hojsak and S. Kolaček, "Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease", Journal of Pediatric Gastroenterology and Nutrition, vol. 70, no. 4, pp. 497-502, April 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:701642. [Accessed: 01 January 2025]

Metadata
Title (english)Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease
AuthorSara Sila
AuthorMarko Jelić
AuthorIvana Trivić
AuthorArjana Tambić Andrašević
AuthorIva Hojsak
AuthorSanja Kolaček
Author's institution(University hospital for infectious diseases "Dr. Fran Mihaljević")
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background and aims:Clinical and experimental data suggest that gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to determine intestinal microbiota in newly diagnosed patients with IBD and to compare it with patients' healthy siblings who share same genetic and environmental background and to healthy unrelated controls.Methods:Molecular approach targeting 16S ribosomal RNA was employed for analyzing the gut microbiota of participants' stool samples. Terminal restriction fragment length polymorphphism analysis was performed.Results:Newly diagnosed pediatric patients with IBD (n=19, 68.4% Crohn disease [CD], mean age 14.8±0.65 years), their unaffected healthy siblings (n=20, mean age 12.8±0.85 years), and unrelated healthy controls (n=19, mean age 10.7±0.8 years) were included. Microbial diversity differed significantly between IBD patients, healthy siblings, and healthy controls (P=0.018 for MspI digestion, P=0.013 for HhaI digestion). No significant difference in microbial diversity was found between healthy siblings and healthy controls. In patients reduced presence of genus Eubacterium, Lactobacillus, Enterobacter and Clostridium, and increased presence of genus Streptococcus, Prevotella and Escherichia, compared with healthy siblings and healthy controls, was found.Conclusion:Newly diagnosed pediatric patients with IBD show significantly less diverse microbiota and microbial composition compared with healthy siblings and healthy controls. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Pediatric Gastroenterology and Nutrition
Numberingvol. 70, no. 4, pp. 497-502
p-ISSN0277-2116
e-ISSN1536-4801
DOIhttps://doi.org/10.1097/MPG.0000000000002611
URN:NBNurn:nbn:hr:127:701642
Publication2020-04
Document URLhttps://onlinelibrary.wiley.com/doi/10.1097/MPG.0000000000002611
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-23 11:02:48