prikaz prve stranice dokumenta Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease
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Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease
Journal of Pediatric Gastroenterology and Nutrition, 70 (2020), 4; 497-502. https://doi.org/10.1097/MPG.0000000000002611
Sila, Sara; Jelić, Marko; Trivić, Ivana; Tambić Andrašević, Arjana; Hojsak, Iva; Kolaček, Sanja

Institucijski repozitorij: Repozitorij stomatološkog fakulteta u Zagrebu

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Sila, S., Jelić, M., Trivić, I., Tambić Andrašević, A., Hojsak, I. i Kolaček, S. (2020). Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition, 70. (4), 497-502. doi: 10.1097/MPG.0000000000002611

Sila, Sara, et al. "Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 70, br. 4, 2020, str. 497-502. https://doi.org/10.1097/MPG.0000000000002611

Sila, Sara, Marko Jelić, Ivana Trivić, Arjana Tambić Andrašević, Iva Hojsak i Sanja Kolaček. "Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease." Journal of Pediatric Gastroenterology and Nutrition 70, br. 4 (2020): 497-502. https://doi.org/10.1097/MPG.0000000000002611

Sila, S., et al. (2020) 'Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease', Journal of Pediatric Gastroenterology and Nutrition, 70(4), str. 497-502. doi: 10.1097/MPG.0000000000002611

Sila S, Jelić M, Trivić I, Tambić Andrašević A, Hojsak I, Kolaček S. Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition [Internet]. 04.2020. [pristupljeno 29.12.2024.];70(4):497-502. doi: 10.1097/MPG.0000000000002611

S. Sila, M. Jelić, I. Trivić, A. Tambić Andrašević, I. Hojsak i S. Kolaček, "Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease", Journal of Pediatric Gastroenterology and Nutrition, vol. 70, br. 4, str. 497-502, Travanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:701642. [Citirano: 29.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:701642
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Naslov (engleski)Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease
AutorSara Sila
AutorMarko Jelić
AutorIvana Trivić
AutorArjana Tambić Andrašević
AutorIva Hojsak
AutorSanja Kolaček
Autorova ustanova(Klinika za infektivne bolesti "Dr. Fran Mihaljević")
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background and aims:Clinical and experimental data suggest that gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to determine intestinal microbiota in newly diagnosed patients with IBD and to compare it with patients' healthy siblings who share same genetic and environmental background and to healthy unrelated controls.Methods:Molecular approach targeting 16S ribosomal RNA was employed for analyzing the gut microbiota of participants' stool samples. Terminal restriction fragment length polymorphphism analysis was performed.Results:Newly diagnosed pediatric patients with IBD (n=19, 68.4% Crohn disease [CD], mean age 14.8±0.65 years), their unaffected healthy siblings (n=20, mean age 12.8±0.85 years), and unrelated healthy controls (n=19, mean age 10.7±0.8 years) were included. Microbial diversity differed significantly between IBD patients, healthy siblings, and healthy controls (P=0.018 for MspI digestion, P=0.013 for HhaI digestion). No significant difference in microbial diversity was found between healthy siblings and healthy controls. In patients reduced presence of genus Eubacterium, Lactobacillus, Enterobacter and Clostridium, and increased presence of genus Streptococcus, Prevotella and Escherichia, compared with healthy siblings and healthy controls, was found.Conclusion:Newly diagnosed pediatric patients with IBD show significantly less diverse microbiota and microbial composition compared with healthy siblings and healthy controls. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Pediatric Gastroenterology and Nutrition
Brojčani podacivol. 70, br. 4, str. 497-502
p-ISSN0277-2116
e-ISSN1536-4801
DOIhttps://doi.org/10.1097/MPG.0000000000002611
URN:NBNurn:nbn:hr:127:701642
Datum objave publikacije2020-04
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1097/MPG.0000000000002611
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-10-23 11:02:48