prikaz prve stranice dokumenta In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration
  Download
PDF 1.41 MB
Scientific paper - Original scientific paper
In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration
Central European Journal of Public Health, 27 (2019), 4; 312-319. https://doi.org/10.21101/cejph.a5216
Gavić, Lidia; Goršeta, Kristina; Glavina, Domagoj; Željezić, Davor; Galić, Nada; Tadin, Antonija

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Gavić, L., Goršeta, K., Glavina, D., Željezić, D., Galić, N. & Tadin, A. (2019). In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration. Central European Journal of Public Health, 27. (4), 312-319. doi: 10.21101/cejph.a5216

Gavić, Lidia, et al. "In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration." Central European Journal of Public Health, vol. 27, no. 4, 2019, pp. 312-319. https://doi.org/10.21101/cejph.a5216

Gavić, Lidia, Kristina Goršeta, Domagoj Glavina, Davor Željezić, Nada Galić and Antonija Tadin. "In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration." Central European Journal of Public Health 27, no. 4 (2019): 312-319. https://doi.org/10.21101/cejph.a5216

Gavić, L., et al. (2019) 'In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration', Central European Journal of Public Health, 27(4), pp. 312-319. doi: 10.21101/cejph.a5216

Gavić L, Goršeta K, Glavina D, Željezić D, Galić N, Tadin A. In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration. Central European Journal of Public Health [Internet]. 2019 December 31 [cited 2024 December 25];27(4):312-319. doi: 10.21101/cejph.a5216

L. Gavić, K. Goršeta, D. Glavina, D. Željezić, N. Galić and A. Tadin, "In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration", Central European Journal of Public Health, vol. 27, no. 4, pp. 312-319, December 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:502600. [Accessed: 25 December 2024]

Metadata
Title (english)In vivo assessment of genotoxicity in buccal cells of children undergoing tooth restoration
AuthorLidia Gavić
AuthorKristina Goršeta
AuthorDomagoj Glavina
AuthorDavor Željezić
AuthorNada Galić
MBZ: 192110
AuthorAntonija Tadin
Author's institutionInstitute for Medical Research and Occupational Health
Author's institution(Zagreb University Hispital Center)
Author's institutionUniversity of Split
School of Medicine
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Objectives: Whereas dental materials came in direct or close contact with oral tissue, it is a great concern about the biocompatibility of those materials. This study was performed to evaluate possible DNA damage to buccal cells exposed to dental materials. Methods: This prospective, longitudinal clinical study was conducted over a three months period. Class II restorations were placed in 60 young patients with no previous filling using one of three tested dental materials (two glass ionomers; Ketac Molar and Ionofil Molar and one compomer material; Twinky Star). DNA damage was analysed by micronucleus assays, in buccal exfoliated epithelial cells. Results: In patients treated with Ketac Molar, a significant frequency of micronuclei (p = 0.027) and binucleated cells in samples taken 30 days following restoration (p = 0.029) was confirmed. In patients treated with Twinky Star, a statistically significant increase in the number of binucleated cells in samples taken after 7 and 30 days following restoration (p = 0.001 and p < 0.001, respectively) was observed. In all samples collected 90 days after treatment, there was no statistical difference in the number of any cell changes. Conclusion: In this study long-term biocompatibility of tested materials was confirmed. Glass ionomers and compomers are widely used materials in paediatric dentistry, and this study has proved their safety for usage in children.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCentral European Journal of Public Health
Numberingvol. 27, no. 4, pp. 312-319
p-ISSN1210-7778
e-ISSN1803-1048
DOIhttps://doi.org/10.21101/cejph.a5216
URN:NBNurn:nbn:hr:127:502600
Publication2019-12-31
Document URLhttp://cejph.szu.cz/doi/10.21101/cejph.a5216.html
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-24 07:34:41