prikaz prve stranice dokumenta CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential
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Scientific paper - Original scientific paper
CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential
Anticancer Research, 36 (2016), 10; 5437-5442. https://doi.org/10.21873/anticanres.11122
Bišćanin, Alen; Ljubičić, Neven; Boban, Marko; Baličević, Drinko; Pavić, Ivana; Bišćanin, Mirela Maver; Budimir, Ivan; Dorosulic, Zdravko; Duvnjak, Marko

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Bišćanin, A., Ljubičić, N., Boban, M., Baličević, D., Pavić, I., Bišćanin, M. M. ... Duvnjak, M. (2016). CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential. Anticancer Research, 36. (10), 5437-5442. doi: 10.21873/anticanres.11122

Bišćanin, Alen, et al. "CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential." Anticancer Research, vol. 36, no. 10, 2016, pp. 5437-5442. https://doi.org/10.21873/anticanres.11122

Bišćanin, Alen, Neven Ljubičić, Marko Boban, Drinko Baličević, Ivana Pavić, Mirela Maver Bišćanin, Ivan Budimir, Zdravko Dorosulic and Marko Duvnjak. "CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential." Anticancer Research 36, no. 10 (2016): 5437-5442. https://doi.org/10.21873/anticanres.11122

Bišćanin, A., et al. (2016) 'CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential', Anticancer Research, 36(10), pp. 5437-5442. doi: 10.21873/anticanres.11122

Bišćanin A, Ljubičić N, Boban M, Baličević D, Pavić I, Bišćanin MM, and sur.. CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential. Anticancer Research [Internet]. 2016 October 12 [cited 2024 December 02];36(10):5437-5442. doi: 10.21873/anticanres.11122

A. Bišćanin, et al., "CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential", Anticancer Research, vol. 36, no. 10, pp. 5437-5442, October 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:127405. [Accessed: 02 December 2024]

Metadata
Title (english)CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential
AuthorAlen Bišćanin
AuthorNeven Ljubičić
AuthorMarko Boban
AuthorDrinko Baličević
AuthorIvana Pavić
AuthorMirela Maver Bišćanin
AuthorIvan Budimir
AuthorZdravko Dorosulic
AuthorMarko Duvnjak
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institution(Zagreb University Hispital Center)
Author's institutionUniversity of Zagreb
School of Medicine
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Background/Aim: Colorectal cancer is a major public health problem. The adenoma-carcinoma sequence offers potential for screening and surveillance. We tested the clinical behavior and diagnostic utility of connexin 43 (CX43) in connection with pathohistological risk. Patients and Methods: Immunohistochemical expression of CX43 in colonic adenomas and surrounding mucosa from 87 patients was determined. Results: CX43 expression was higher in mucosa surrounding adenomas with high-grade dysplasia (p=0.047), larger adenomas (p=0.015) and villous adenomas (p=0.02). No difference of CX43 expression in adenomas according to grade of dysplasia was found (p=0.87). CX43 expression in adenomas was dependent on the patient's hemoglobin level (p=0.002), family history of colorectal cancer (p=0.009) and statin therapy (p=0.049). Conclusion: CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAnticancer Research
Numberingvol. 36, no. 10, pp. 5437-5442
p-ISSN0250-7005
e-ISSN1791-7530
DOIhttps://doi.org/10.21873/anticanres.11122
URN:NBNurn:nbn:hr:127:127405
Publication2016-10-12
Document URLhttp://ar.iiarjournals.org/content/36/10/5437.abstract
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-30 08:59:03