prikaz prve stranice dokumenta Local drug delivery for oral mucosal diseases: challenges and opportunities
  Download
PDF 279.45 KB
Scientific paper - Original scientific paper
Local drug delivery for oral mucosal diseases: challenges and opportunities
Oral Diseases, 17 (2011), s1; 73-84. https://doi.org/10.1111/j.1601-0825.2011.01793.x
Sankar, V; Hearnden, V; Hull, K; Juras, D Vidovic; Greenberg, MS; Kerr, AR; Lockhart, PB; Patton, LL; Porter, S; Thornhill, M

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Sankar, V., Hearnden, V., Hull, K., Juras, D. V., Greenberg, M., Kerr, A. ... Thornhill, M. (2011). Local drug delivery for oral mucosal diseases: challenges and opportunities. Oral Diseases, 17. (s1), 73-84. doi: 10.1111/j.1601-0825.2011.01793.x

Sankar, V, et al. "Local drug delivery for oral mucosal diseases: challenges and opportunities." Oral Diseases, vol. 17, no. s1, 2011, pp. 73-84. https://doi.org/10.1111/j.1601-0825.2011.01793.x

Sankar, V, V Hearnden, K Hull, D Vidovic Juras, MS Greenberg, AR Kerr, PB Lockhart, LL Patton, S Porter and M Thornhill. "Local drug delivery for oral mucosal diseases: challenges and opportunities." Oral Diseases 17, no. s1 (2011): 73-84. https://doi.org/10.1111/j.1601-0825.2011.01793.x

Sankar, V., et al. (2011) 'Local drug delivery for oral mucosal diseases: challenges and opportunities', Oral Diseases, 17(s1), pp. 73-84. doi: 10.1111/j.1601-0825.2011.01793.x

Sankar V, Hearnden V, Hull K, Juras DV, Greenberg M, Kerr A, and sur.. Local drug delivery for oral mucosal diseases: challenges and opportunities. Oral Diseases [Internet]. 2011 March 08 [cited 2024 December 26];17(s1):73-84. doi: 10.1111/j.1601-0825.2011.01793.x

V. Sankar, et al., "Local drug delivery for oral mucosal diseases: challenges and opportunities", Oral Diseases, vol. 17, no. s1, pp. 73-84, March 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:528901. [Accessed: 26 December 2024]

Metadata
Title (english)Local drug delivery for oral mucosal diseases: challenges and opportunities
AuthorV Sankar
AuthorV Hearnden
AuthorK Hull
AuthorD Vidovic Juras
AuthorMS Greenberg
AuthorAR Kerr
AuthorPB Lockhart
AuthorLL Patton
AuthorS Porter
AuthorM Thornhill
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
There are few topical formulations used for oral medicine applications most of which have been developed for the management of dermatological conditions. As such, numerous obstacles are faced when utilizing these preparations in the oral cavity, namely enzymatic degradation, taste, limited surface area, poor tissue penetration and accidental swallowing. In this review, we discuss common mucosal diseases such as oral cancer, mucositis, vesiculo‐erosive conditions, infections, neuropathic pain and salivary dysfunction, which could benefit from topical delivery systems designed specifically for the oral mucosa, which are capable of sustained release. Each condition requires distinct penetration and drug retention profiles in order to optimize treatment and minimize side effects. Local drug delivery may provide a more targeted and efficient drug‐delivery option than systemic delivery for diseases of the oral mucosa. We identify those mucosal diseases currently being treated, the challenges that must be overcome and the potential of novel therapies. Novel biological therapies such as macromolecular biological drugs, peptides and gene therapy may be of value in the treatment of many chronic oral conditions and thus in oral medicine if their delivery can be optimized.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleOral Diseases
Numberingvol. 17, no. s1, pp. 73-84
p-ISSN1354-523X
e-ISSN1601-0825
DOIhttps://doi.org/10.1111/j.1601-0825.2011.01793.x
URN:NBNurn:nbn:hr:127:528901
Publication2011-03-08
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01793.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-31 10:09:02