prikaz prve stranice dokumenta Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease
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Scientific paper - Original scientific paper
Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease
Medicina, 60 (2024), 11; 1886. https://doi.org/10.3390/medicina60111886
Glavina, Ana; Zurak, Petar; Martinović, Dinko; Gotovac, Majda; Šupe-Domić, Daniela; Lugović-Mihić, Liborija

Institutional repository: University of Zagreb School of Dental Medicine Repository

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Glavina, A., Zurak, P., Martinović, D., Gotovac, M., Šupe Domić, D. & Lugović Mihić, L. (2024). Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease. Medicina, 60. (11). doi: 10.3390/medicina60111886

Glavina, Ana, et al. "Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease." Medicina, vol. 60, no. 11, 2024. https://doi.org/10.3390/medicina60111886

Glavina, Ana, Petar Zurak, Dinko Martinović, Majda Gotovac, Daniela Šupe Domić and Liborija Lugović Mihić. "Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease." Medicina 60, no. 11 (2024). https://doi.org/10.3390/medicina60111886

Glavina, A., et al. (2024) 'Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease', Medicina, 60(11). doi: 10.3390/medicina60111886

Glavina A, Zurak P, Martinović D, Gotovac M, Šupe Domić D, Lugović Mihić L. Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease. Medicina [Internet]. 2024 November 17 [cited 2024 December 24];60(11). doi: 10.3390/medicina60111886

A. Glavina, P. Zurak, D. Martinović, M. Gotovac, D. Šupe Domić and L. Lugović Mihić, "Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease", Medicina, vol. 60, no. 11, November 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:487363. [Accessed: 24 December 2024]

Metadata
Title (english)Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease
AuthorAna Glavina
AuthorPetar Zurak
AuthorDinko Martinović
AuthorMajda Gotovac
AuthorDaniela Šupe-Domić
AuthorLiborija Lugović-Mihić
Author's institutionUniversity of Split
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background and Objectives: Patients with primary Sjögren’s disease (pSjD) show contradictory results regarding the activity of the hypothalamic–pituitary–adrenal (HPA) axis. The aim of this study was to determine the salivary cortisol concentration to evaluate the function of the HPA axis (hypoactive/hyperactive) between patients with pSjD and control subjects. Materials and Methods: A total of 34 subjects participated in the cross-sectional study: 17 patients with pSjD and 17 control subjects. Stimulated whole saliva (SWS) was used to determine salivary cortisol concentration using an enzyme-linked immunosorbent assay (ELISA). Results: The salivary cortisol concentration showed a statistically significant difference between patients with pSjD and control subjects (4.69 ± 2.88 vs. 0.49 ± 0.37; p < 0.001; Student t-test). The area under the curve (AUC) was 100.0% in patients with pSjD (p < 0.001). The cut-off point was set to >1.454. The patients with pSjD had four times higher scores for depression and stress and six times higher scores for anxiety compared to the control subjects (p = 0.048, p < 0.001, p = 0.038; Mann–Whitney U test). The patients with pSjD had a statistically significantly higher total Oral Health Impact Profile (OHIP) score compared to the control subjects (p < 0.001, Mann–Whitney U test). Conclusions: The patients with pSjD showed short-term hyperactivity of the HPA axis compared to the control subjects.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedicina
Numberingvol. 60, no. 11, 1886
e-ISSN1648-9144
DOIhttps://doi.org/10.3390/medicina60111886
URN:NBNurn:nbn:hr:127:487363
Publication2024-11-17
Document URLhttps://www.mdpi.com/1648-9144/60/11/1886
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-12-20 12:15:41