prikaz prve stranice dokumenta Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease
  Preuzmi
PDF 584.07 KB
Znanstveni rad - Izvorni znanstveni rad
Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease
Medicina, 60 (2024), 11; 1886. https://doi.org/10.3390/medicina60111886
Glavina, Ana; Zurak, Petar; Martinović, Dinko; Gotovac, Majda; Šupe-Domić, Daniela; Lugović-Mihić, Liborija

Institucijski repozitorij: Repozitorij stomatološkog fakulteta u Zagrebu

Citirajte ovaj rad

Glavina, A., Zurak, P., Martinović, D., Gotovac, M., Šupe Domić, D. i Lugović Mihić, L. (2024). Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease. Medicina, 60. (11). doi: 10.3390/medicina60111886

Glavina, Ana, et al. "Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease." Medicina, vol. 60, br. 11, 2024. https://doi.org/10.3390/medicina60111886

Glavina, Ana, Petar Zurak, Dinko Martinović, Majda Gotovac, Daniela Šupe Domić i Liborija Lugović Mihić. "Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease." Medicina 60, br. 11 (2024). https://doi.org/10.3390/medicina60111886

Glavina, A., et al. (2024) 'Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease', Medicina, 60(11). doi: 10.3390/medicina60111886

Glavina A, Zurak P, Martinović D, Gotovac M, Šupe Domić D, Lugović Mihić L. Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease. Medicina [Internet]. 17.11.2024. [pristupljeno 24.12.2024.];60(11). doi: 10.3390/medicina60111886

A. Glavina, P. Zurak, D. Martinović, M. Gotovac, D. Šupe Domić i L. Lugović Mihić, "Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease", Medicina, vol. 60, br. 11, Studeni 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:487363. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:487363
Podaci o radu
Naslov (engleski)Evaluation of the Hypothalamic–Pituitary–Adrenal Axis in Patients with Primary Sjögren’s Disease
AutorAna Glavina
AutorPetar Zurak
AutorDinko Martinović
AutorMajda Gotovac
AutorDaniela Šupe-Domić
AutorLiborija Lugović-Mihić
Autorova ustanovaSveučilište u Splitu
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background and Objectives: Patients with primary Sjögren’s disease (pSjD) show contradictory results regarding the activity of the hypothalamic–pituitary–adrenal (HPA) axis. The aim of this study was to determine the salivary cortisol concentration to evaluate the function of the HPA axis (hypoactive/hyperactive) between patients with pSjD and control subjects. Materials and Methods: A total of 34 subjects participated in the cross-sectional study: 17 patients with pSjD and 17 control subjects. Stimulated whole saliva (SWS) was used to determine salivary cortisol concentration using an enzyme-linked immunosorbent assay (ELISA). Results: The salivary cortisol concentration showed a statistically significant difference between patients with pSjD and control subjects (4.69 ± 2.88 vs. 0.49 ± 0.37; p < 0.001; Student t-test). The area under the curve (AUC) was 100.0% in patients with pSjD (p < 0.001). The cut-off point was set to >1.454. The patients with pSjD had four times higher scores for depression and stress and six times higher scores for anxiety compared to the control subjects (p = 0.048, p < 0.001, p = 0.038; Mann–Whitney U test). The patients with pSjD had a statistically significantly higher total Oral Health Impact Profile (OHIP) score compared to the control subjects (p < 0.001, Mann–Whitney U test). Conclusions: The patients with pSjD showed short-term hyperactivity of the HPA axis compared to the control subjects.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedicina
Brojčani podacivol. 60, br. 11, 1886
e-ISSN1648-9144
DOIhttps://doi.org/10.3390/medicina60111886
URN:NBNurn:nbn:hr:127:487363
Datum objave publikacije2024-11-17
URL dokumentahttps://www.mdpi.com/1648-9144/60/11/1886
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-20 12:15:41