| Abstract | Veterinarska medicina još nije dostigla napredak u odnosu na humanu medicinu, u vidu broja dostupnih objektivnih i nepristranih znanstvenih dokaza za uporabu medicinskog kanabisa. To je dijelom, zbog činjenice što legalizirajuća tijela ne predviđaju jednake legalne privilegije za veterinare kakve liječnici imaju za preporučivanje kanabisa svojim pacijentima, unatoč jasnim dokazima o sigurnosti kanabinoida kod životinja. Ipak, danas postoji nekoliko sveučilišnih, prospektivnih, dvostruko-slijepih, placebo-kontroliranih i nasumičnih kliničkih studija koje su ispitale sigurnost i farmakokinetiku CBD-a izoliranog iz konoplje, u terapiji osteoartritisa i epilepsije, te postoji dostatan broj dokaza koji podupiru uporabu kanabisa kod veterinarskih pacijenata sa karcinomom. Zbog gotovo univerzalne distribucije ECS-a u svih kralježnjaka i kod mnogih beskralježnjaka, iste ili slične dobrobiti kanabinoida dokazane kod ljudi, također se mogu očekivati kod većine životinja. Liječenje kanabinoidima je vrlo specifično zato što još uvijek nisu definirane službene smjernice za njegovu uporabu, stoga je potrebno pomno praćenje pacijenata. Primijećene koristi od uporabe kanabisa uključuju: smanjenje anksioznosti, olakšanje boli, poboljšanje mobilnosti u životinja s osteoartritisom, smanjenje veličine tumora, poboljšanje apetita, poboljšana kontrola dijabetesa tipa 2 i ublažavanje gastrointestinalnih poremećaja, upalnih stanja, te bolja kontrola epileptičnih napadaja. Ove koristi nisu univerzalne, i uspješni tretmani se temelje na doziranjus obzirom na vrstu i težinu stanja, brzini metabolizma i čimbenicima povezanim s biokemijskom raznolikošću, gustoćom i raspodjelom ECS-a među članovima iste vrste. Veterinari, veterinarski istraživači i skrbnici životinja koji nemaju predrasude i prihvaćaju terapiju na bazi kanabisa, željno traže dokaze koji bi podržali sigurnu i učinkovitu primjenu kanabinoida za njihove ljubimce ili pacijente, te je nužno bolje razumjeti ovu fascinantnu i emergentnu vrstu terapije. Shvaćanjem njenog principa djelovanja, uspješnije se mogu određivati kanabinoidne terapije i formulirati učinkovitiji kanabinoidni lijekovi. |
| Abstract (english) | Veterinary medicine hasn't reached the same advances in comparison to human medicine in terms of objective and unbiased scientific evidence available for the use of medical cannabis. This is in part, due to the fact, that the legalizing bodies do not provide the same legal privileges for veterinarians as doctors have for recommending cannabis to their human patients, despite sufficient evidence of proven safety of cannabinoids for veterinary patients. Nevertheless, today, there are several university, prospective, double-blinded, placebo-controlled, and randomized clinical studies that have examined the safety and pharmacokinetics of CBD isolated from hemp and the efficacy of hemp oil extract in the treatment of osteoarthritis and epilepsy, as well as there are sufficient data supporting cannabis use in veterinary cancer patients. Due to the almost universal distribution of ECS in all vertebrates, and in many invertebrates, the same or similar capabilities of cannabinoids proven in humans can also be applied in most veterinary species. Cannabinoid treatment is very specific, as no formal guidance for its use and dosages have been defined yet, so close monitoring of patients is required. Cannabis has been observed to help with: reducing anxiety, facilitating increased mobility in animals with osteoarthritis, reducing tumor size, increasing appetite, improving control of type 2 diabetes and alleviating GI disorders, inflammatory conditions, and better control of seizures. These results were not universal, and successful treatments were based on dosages with respect to type and severity of the condition, metabolic rate, factors including biochemical diversity, density and distribution of ECS among the members of the same species. Veterinarians, veterinary researchers and caregivers that are open minded and receptive of cannabis-based therapies, are eager to find scientific evidence of safety and efficiency of cannabinoid therapies for their pets or patients, so it is an imperative to better research this fascinating and extraordinary new therapy and by understaning its principle of action to more successfully prescribe cannabinoid therapies and formulate more efficient cannabinoid drugs. |
