Veterinary medicine hasn't reached the same advances in comparison to human medicine in terms of objective and unbiased scientific evidence available for the use of medical cannabis. This is in part, due to the fact, that the legalizing bodies do not provide the same legal privileges for veterinarians as doctors have for recommending cannabis to their human patients, despite sufficient evidence of proven safety of cannabinoids for veterinary patients. Nevertheless, today, there are several university, prospective, double-blinded, placebo-controlled, and randomized clinical studies that have examined the safety and pharmacokinetics of CBD isolated from hemp and the efficacy of hemp oil extract in the treatment of osteoarthritis and epilepsy, as well as there are sufficient data supporting cannabis use in veterinary cancer patients. Due to the almost universal distribution of ECS in all vertebrates, and in many invertebrates, the same or similar capabilities of cannabinoids proven in humans can also be applied in most veterinary species. Cannabinoid treatment is very specific, as no formal guidance for its use and dosages have been defined yet, so close monitoring of patients is required. Cannabis has been observed to help with: reducing anxiety, facilitating increased mobility in animals with osteoarthritis, reducing tumor size, increasing appetite, improving control of type 2 diabetes and alleviating GI disorders, inflammatory conditions, and better control of seizures. These results were not universal, and successful treatments were based on dosages with respect to type and severity of the condition, metabolic rate, factors including biochemical diversity, density and distribution of ECS among the members of the same species. Veterinarians, veterinary researchers and caregivers that are open minded and receptive of cannabis-based therapies, are eager to find scientific evidence of safety and efficiency of cannabinoid therapies for their pets or patients, so it is an imperative to better research this fascinating and extraordinary new therapy and by understaning its principle of action to more successfully prescribe cannabinoid therapies and formulate more efficient cannabinoid drugs.