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master's thesis
Primjena eutektičkih otapala u reakciji kvaternizacije izonikotinamida i supstituiranih 2-bromacetofenona
Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2019. urn:nbn:hr:109:110519
Božanović, Dalia
Josip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Department of Applied Chemistry and Ecology
Sub-department of Chemistry and Ecology

Institutional repository: Repository of the Faculty of Food Technology Osijek

Cite this document

Božanović, D. (2019). Primjena eutektičkih otapala u reakciji kvaternizacije izonikotinamida i supstituiranih 2-bromacetofenona (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY. Retrieved from https://urn.nsk.hr/urn:nbn:hr:109:110519

Božanović, Dalia. "Primjena eutektičkih otapala u reakciji kvaternizacije izonikotinamida i supstituiranih 2-bromacetofenona." Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2019. https://urn.nsk.hr/urn:nbn:hr:109:110519

Božanović, Dalia. "Primjena eutektičkih otapala u reakciji kvaternizacije izonikotinamida i supstituiranih 2-bromacetofenona." Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2019. https://urn.nsk.hr/urn:nbn:hr:109:110519

Božanović, D. (2019). 'Primjena eutektičkih otapala u reakciji kvaternizacije izonikotinamida i supstituiranih 2-bromacetofenona', Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, accessed 24 December 2024, https://urn.nsk.hr/urn:nbn:hr:109:110519

Božanović D. Primjena eutektičkih otapala u reakciji kvaternizacije izonikotinamida i supstituiranih 2-bromacetofenona [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY; 2019 [cited 2024 December 24] Available at: https://urn.nsk.hr/urn:nbn:hr:109:110519

D. Božanović, "Primjena eutektičkih otapala u reakciji kvaternizacije izonikotinamida i supstituiranih 2-bromacetofenona", Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:109:110519

Metadata
TitlePrimjena eutektičkih otapala u reakciji kvaternizacije izonikotinamida i supstituiranih 2-bromacetofenona
Title (english)Application of Eutectic Solvents in the Quaternization Reaction of Isonicotinamide and 2-Bromoacetophenones
AuthorDalia Božanović
MentorValentina Bušić (mentor)
MentorDajana Gašo-Sokač (komentor)
Committee memberMaja Molnar (predsjednik povjerenstva)
Committee memberValentina Bušić (član povjerenstva)
Committee memberDajana Gašo-Sokač (član povjerenstva)
Committee memberIvica Strelec (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
(Department of Applied Chemistry and Ecology)
(Sub-department of Chemistry and Ecology)
Osijek
Defense date and country2019-05-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
U ovom su radu izvedene reakcije kvaternizacije izonikotinamida (INA) kao nukleofila s 2-brom-4-kloracetofenonom, 2-bromacetofenonom i 2-brom-4-metilacetofenonom kao elektrofilima. Reakcije kvaternizacije su po prvi put izvršene u eutektičkim otapalima na bazi kolin-klorida (ChCl). Za reakcije su korištene tri metode: konvencionalna metoda uz miješanje i zagrijavanje, metoda pod utjecajem mikrovalnog zračenja te metoda pod utjecajem ultrazvuka. Iz dobivenih je rezultata vidljivo kako su eutektička otapala kao „zeleni“ medij dobra alternativa za izvođenje reakcija kvaternizacije u skladu s principima zelene kemije. Od eutektičkih otapala kao zelenog medija najbolje su se pokazala otapala ChCl : glicerol, ChCl : jabučna kiselina, ChCl : N-metilurea, ChCl : levulinska kiselina. Za reakciju kvaternizacije najviši prinosi su postignuti mikrovalnom sintezom gdje je u reakciji INA s 2-bromacetofenonom u eutektičkom otapalu ChCl : glicerol skoro postignuto kvantitativno iskorištenje.
Abstract (english)
In this paper, quaternization reactions of isonicotinamide (INA) as nucleophiles with 2-bromo-4-chloroacetophenone, 2-bromoacetophenone and 2-bromo-4-methylacetophenone as electrophiles were performed. Quaternization reactions were performed for the first time in choline chloride (ChCl) based eutectic solvents. Three methodes were used for the reaction: a conventional method with stirring and heating, a method under the influence of microwave irradiation, and an ultrasound method. The results obtained show that eutectic solvents as a "green" medium are a good alternative for carrying out quaternization reactions which is in accordance with the principles of green chemistry. From the eutectic solvents as green media, the most preferred solvents were ChCl : glycerol, ChCl : malic acid, ChCl : N-methylurea, ChCl : Levulinic acid. For the quaternization reaction, the highest yields were achieved by microwave synthesis where in the INA reaction with 2-bromoacetophenone in the eutectic ChCl : glycerol solvent was almost achieved quantitative yield.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:109:110519
Study programmeTitle: Food Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka prehrambenog inženjerstva (magistar/magistra inženjer/inženjerka prehrambenog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-06-05 11:01:19