When protecting crops from pests, it is common in practice for treatment against weeds to coincide with the need for treatment against diseases, pests, growth regulators, and/or foliar fertilization. The possibility of combining different agrochemicals in a tank mix without adverse effects on the crop is poorly understood. . To investigate the selectivity of wheat depending on the combination of agrochemicals, a field trial with winter wheat of the Mia variety was conducted in Jagodno (Velika Gorica) in the 2021 growing season. In the trial, besides an untreated control, combinations of the following preparations were used: of herbicides AXIAL 50 EC (pinoxaden) and SARACEN DELTA 550 SC (florasulam + diflufenican), fungicide PROSARO 250 EC (tebuconazole + prothioconazole), foliar fertilizer under code A 18 ) and growth regulator MODUS EVO DC (trinexapac-ethyl) in eight different mutual combinations of these preparations. The treatment was applied on 09. 04. 2021. at the developmental stage of wheat BBCH 31-32 Visual assessment of damage to each combination was performed 7 and 14 days after treatment on a scale from 0 to 100%. All treatments caused some phytotoxic effect on wheat plants. The symptoms of phytotoxic effect appeared in the form of whitish spots of irregular shape. The least damage (from 3.0 to 4.3%) had a combination of herbicides and a combination of herbicides + fertilizer and herbicides + growth regulator. The greatest damage of progressive character was caused by the combinations of herbicides + growth regulator + fungicide (7.7 and 15.3%), herbicides + fungicide + fertilizer (4.7 and 10.7%) and the combination of herbicide + fungicide + fertilizer + growth regulator (9.3 and 13.7%).