Methamphetamine and other psychostimulants can instigate many physiological changes that lead to the misregulation of the dopamine signaling pathway in humans. Extended use can cause permanent changes in this signaling pathway due to neuroplasticity, and those changes are carried into the next generation by certain epigenetic modifications that affect gene expression. As a result, a phenotype with an increased locomotor activity is created and persists even without the initial stimuli. The purpose of this thesis was to investigate how volazilized methamphetamine (vMETH) affects the creation of the new phenotype in the F1 generation of Drosophile melanogaster. vMETH is administered using the FlyBong method to a group of male flies and 23% of them were selected based on locomotor activity. They were then bred with untreated virgin flies. The effects of the methamphetamine dose wer observed in the F1 generation by measuring locomotor activity. Results have shown a statistically higher activity in the F1 treated group, but there was no statistically significant difference between the control and the treated group. This could point to the existance of the mentioned phenotype, which should be investigated through several generations.