prikaz prve stranice dokumenta In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism
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In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism
ChemMedChem, 13 (2018), 4; 360-372. https://doi.org/10.1002/cmdc.201700748
Jelovica, Mateo; Grbčić, Petra; Mušković, Martina; Sedić, Mirela; Pavelić, Sandra Kraljević; Lončarić, Martin; Malatesti, Nela

Institucijski repozitorij: Repozitorij Fakulteta biotehnologije i razvoja lijekova

Citirajte ovaj rad

Jelovica, M., Grbčić, P., Mušković, M., Sedić, M., Pavelić, S. K., Lončarić, M. i Malatesti, N. (2018). In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism. ChemMedChem, 13. (4), 360-372. doi: 10.1002/cmdc.201700748

Jelovica, Mateo, et al. "In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism." ChemMedChem, vol. 13, br. 4, 2018, str. 360-372. https://doi.org/10.1002/cmdc.201700748

Jelovica, Mateo, Petra Grbčić, Martina Mušković, Mirela Sedić, Sandra Kraljević Pavelić, Martin Lončarić i Nela Malatesti. "In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism." ChemMedChem 13, br. 4 (2018): 360-372. https://doi.org/10.1002/cmdc.201700748

Jelovica, M., et al. (2018) 'In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism', ChemMedChem, 13(4), str. 360-372. doi: 10.1002/cmdc.201700748

Jelovica M, Grbčić P, Mušković M, Sedić M, Pavelić SK, Lončarić M, i sur.. In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism. ChemMedChem [Internet]. 2018. [pristupljeno 29.11.2024.];13(4):360-372. doi: 10.1002/cmdc.201700748

M. Jelovica, et al., "In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism", ChemMedChem, vol. 13, br. 4, str. 360-372, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:812786. [Citirano: 29.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:193:812786
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Naslov (engleski)In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism
AutorMateo Jelovica
AutorPetra Grbčić
AutorMartina Mušković
AutorMirela Sedić
AutorSandra Kraljević Pavelić
AutorMartin Lončarić
AutorNela Malatesti
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Znanstveno / umjetničko
područje, polje i grana		INTERDISCIPLINARNA PODRUČJA ZNANOSTI
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Sažetak (engleski)
A series of N-methylated and N-oxidised tripyridyl porphyrins were synthesised, characterised, and their PDT activity was studied with six cell lines. All the tested porphyrins with a long alkyl chain, except one, were more efficient for PDT than an N- methylated hydrophilic porphyrin and N-oxidised porphyrin without the long alkyl chain. Generally, N-methylated tripyridyl porphyrins were more active than those N-oxidised, but IC50 values for phototoxicity of two N-oxides, named TOPyP3-C17H33O and TOPyP3-C17H35, were still in the nanomolar concentration range for most of the tested cell lines. However, TOPyP3- C17H35 did not show phototoxicity on human foreskin fibroblast cells. Two methylated amphiphilic porphyrins, named TMPyP3-C17H33 and TMPyP4-C17H35, showed significant dark toxicity, whereas none of the oxidopyridyl porphyrins were toxic without light activation. The selected photosensitisers were shown to be apoptosis inducers, and had inhibitory effects on the clonogenic growth of HCT116 and HeLa cells. All three N-methylated amphiphilic porphyrins significantly reduced the migratory potential of HCT116 cells. Porphyrins TMPyP3- C17H35 and TOPyP3-C17H35 reduced the activity of acid ceramidase, whereas TOPyP3-C17H33O had a significant inhibitory effect on sphingosine kinase 1 activity in HeLa cells. Compounds with this dual activity were shown to be the most promising photosensitisers, with potential to treat invasive cancers.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeRukopis poslan na recenzijski postupak (preprint)
Naslov časopisaChemMedChem
Brojčani podacivol. 13, br. 4, str. 360-372
p-ISSN1860-7179
DOIhttps://doi.org/10.1002/cmdc.201700748
URN:NBNurn:nbn:hr:193:812786
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/922747
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-09-13 13:45:23