prikaz prve stranice dokumenta Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study
  Preuzmi
PDF 3.75 MB
Znanstveni rad - Izvorni znanstveni rad
Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study
Pharmaceuticals, 16 (2023), 2; 251-269. https://doi.org/10.3390/ph16020251
Novak, Jurica; Tseilikman, Vadim E.; Tseilikman, Olga B.; Lazuko, Svetlana S.; Belyeva, Lyudmila E.; Rahmani, Azam; Fedotova, Julia

Institucijski repozitorij: Repozitorij Fakulteta biotehnologije i razvoja lijekova

Citirajte ovaj rad

Novak, J., Tseilikman, V. E., Tseilikman, O. B., Lazuko, S. S., Belyeva, L. E., Rahmani, A. i Fedotova, J. (2023). Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study. Pharmaceuticals, 16. (2), 251-269. doi: 10.3390/ph16020251

Novak, Jurica, et al. "Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study." Pharmaceuticals, vol. 16, br. 2, 2023, str. 251-269. https://doi.org/10.3390/ph16020251

Novak, Jurica, Vadim E. Tseilikman, Olga B. Tseilikman, Svetlana S. Lazuko, Lyudmila E. Belyeva, Azam Rahmani i Julia Fedotova. "Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study." Pharmaceuticals 16, br. 2 (2023): 251-269. https://doi.org/10.3390/ph16020251

Novak, J., et al. (2023) 'Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study', Pharmaceuticals, 16(2), str. 251-269. doi: 10.3390/ph16020251

Novak J, Tseilikman VE, Tseilikman OB, Lazuko SS, Belyeva LE, Rahmani A, i sur.. Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study. Pharmaceuticals [Internet]. 07.02.2023. [pristupljeno 27.11.2024.];16(2):251-269. doi: 10.3390/ph16020251

J. Novak, et al., "Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study", Pharmaceuticals, vol. 16, br. 2, str. 251-269, Veljača 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:201396. [Citirano: 27.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:193:201396
Podaci o radu
Naslov (engleski)Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study
AutorJurica Novak
AutorVadim E. Tseilikman
AutorOlga B. Tseilikman
AutorSvetlana S. Lazuko
AutorLyudmila E. Belyeva
AutorAzam Rahmani
AutorJulia Fedotova
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Kemija
Teorijska kemija
Sažetak (engleski)
The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) is an NADPH-dependent reductase, responsible for the activation of cortisol by reducing cortisone. Resveratrol (RES), a type of natural polyphenol, is reported to be able to slow the progression of cancer and cardiovascular disease and improve the health of mice on a high- calorie diet. In this article, we applied molecular docking and molecular dynamics simulations to investigate the possibility of binding RES to 11β-HSD-1. The 11β-HSD-1:RES complex is stable on the μs time scale, and backbone RMSD-based clustering identified three conformations. Special attention was paid to the interaction pattern between the ligand and the target molecule, revealing hydrogen bonds between the hydroxyl group of RES and Thr124, as well as hydrophobic interactions responsible for the binding. In vivo studies demonstrated the ability of resveratrol at a dose of 40 mg/kg to reduce 11β-HSD-1 activity in the liver of rats under conditions of experimental post-traumatic stress disorder (PTSD), as well as in non-stressed animals. In both cases, the resveratrol-induced reduction in 11β-HSD-1 activity was accompanied by an increase in plasma corticosterone levels and a decrease in anxiety levels in the plus maze test.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPharmaceuticals
Brojčani podacivol. 16, br. 2, str. 251-269
p-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph16020251
URN:NBNurn:nbn:hr:193:201396
Datum objave publikacije2023-02-07
URL dokumentahttps://www.mdpi.com/1424-8247/16/2/251
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-02-12 19:24:39