Starting from the analysis of Genesis 1, 26-27, this paper discusses the meaning of the biblical account of human creation and its meaning for contemporary anthropological thought. Theological Anthropology of Pope John Paul II. is the central theme of this work. Pope John Paul II. was a theologian who successfully rehabilitated the biblical collocation man - the image of God. The Pope places this truth of biblical anthropology at the center of his teaching. He exposes the interpretation of man within the mysteries of the Holy Trinity and the mysteries of Christ. In this way, he exposes the meaning of the biblical words in Genesis 1, 26-27, to which man is understood as a personal being, characterized by qualities of unity of soul and body, rationality and freedom, communitarian dimensions, and creativity and procreatio The anthropology that starts from the collocation man - the image of God confirms that the report on the creation of man in Genesis 1, 26-27 represents the first and the last speech about man. Any subsequent anthropology and speech about man will only be a more detailed interpretation of what God has already told us in the first pages of the Bible Theological Anthropology of Pope John Paul II. will be a stronghold for Christian theology and for the believers of the Catholic Church while they are facing the challenges of modern society. The technical advancement and development of society may give man a means of simpler existence, but it seems that people become the same over time. This is the paradox of the modern man who loses the meaning of his own existence, and as the only answer Pope John Paul II. brings back the fundamental truth - man is the image of God.