Women offenders represent a small minority in correctional systems worldwide. This is stated as a legitimate reason why the treatment of women has long been based on knowledge gained through research with the male offenders population. The result were interventions based on principle “one-size-fits-all”. Research confirms that women offenders differ significantly from their male counterparts in terms of their personal histories and their pathways to crime. The acknowledgement that „gender makes a difference“ was the foremost step to respond appropriately to their unique, „gender specific“ needs. There are many principles of effective rehabilitation for offenders, but programs based on the widely accepted Risk-Need-Responsivity model of rehabilitation (RNR) have shown the best results. Therefore, this work will present the specifics of women's treatment through the prism of the RNR approach to the assessment and treatment of women offenders. An integrative perspective of women offenders treatment is used as a landmark text, which forms the backbone of this work. Additionally, the results of other relevant research that focused on women will be presented. Given the indivisibility of theory and practice, this work presents the specificity of women's treatment through issues related to theory, assessment and elements of effective response to treatment. The specificity of women's treatment in penal system is reflected in the need for an integrated holistic approach. Therefore this work offers a comprehensive perspective on this issue. Increased sensitivity to specific women's needs is necessary in order to design effective programs over the long term. According to that, the assessment and treatment of women offenders should attend to important contextual factors of their lives (e.g., experiences of trauma, mental health problems, substance abuse) and leverage women‟s strengths to promote healing and desistence from crime