Parents have a key role in the care and upbringing of their child. In families of children with developmental difficulties this role is even greater. Numerous studies have shown that families of children with developmental difficulties are exposed to daily mental and physical efforts. Apart from the implementation of programs and/or assessment and direct work with children with disabilities, the task of the educational rehabilitator is to support, empower and understand their parents. In order to achieve this, it is important to take into account their perceived quality of life. The problem of this research is to examine whether there are differences in the subjective peceived quality of life between parents of children without disabilities, parents of children with intellectual and associated difficulties and parents of children with ASD, as well as determining the difference between mothers and fathers. The study involved 182 parents. The research was conducted in the city of Osijek. Three questionnaires were used for the quality of life survey: PWI (Personal Wellbeing Index), WHOQOL-BREF questionnaire and Generic Inquiry. Research findings show that there is a statistically significant difference in the estimated quality of life between parents of children without disabilities and parents of children with disabilities in most dimensions of PWI and WHOQOL-BREF categories. Statistically significant differences in the estimated quality of life of parents with regard to the child's difficulty have not been established. Furthermore, given the gender of the respondents, a statistically significant difference was found between the mothers of children with disabilities and the mothers of children of neat development in three dimensions of PWI instrument, but there was no statistically significant difference between the fathers of children with disabilities and fathers of neat development in any dimension. Given the differences between mothers and fathers of children with disabilities, statistically significant difference was established only in one dimension PWI instrument, while in the overall quality of life no statistically significant differences were found.