During its lifetime, a woman's body passes through a number of physical changes, from those relatively transient, frequent and benign, to those which are concealed and not so obvious and may point to a pathological condition. Pathological changes include breast cancer, which is the most common cancer among women in developed countries. Increasingly, malignant changes occur in younger populations, so it is important to educate specifically that population in time in order to detect changes and thus preserve their health. The research was carried out by quantitative and qualitative methodology. The semple was included 145 high school female students. The aims of the research were to gain insight into the awareness of high school femal students about breast cancer (symptomatology, treatment, risk factors, personal experience, etc.), and breast self-examination (BSE) as a way of early detection of the disease; to conduct and evaluate the BSE educational program within the same group of students and to encourage them to regularly perform it and evaluate the effect of this BSE educational program in terms of frequency and regularity during 5 months. The qualitative part is aimed towards gaining insight into the thinking of high school female students about breast cancer and self-examination after a completed BSE educational program, what their feelings are about it and what they think of the implemented program. The emphasis is placed on the students own perspectives. The results of the research have shown that the awareness of high school students on breast cancer and BSE em was relatively low, and after the implemented education program, the results of the evaluation showed that the program was useful to the students. After 5 months, the frequency of BSE was evaluated, and the results showed that most of them performed BSE at least ones, while the regular one-monthly BSE was conducted by the third of respondent. The results of the qualitative part of the research have shown that high school students in the education programs of BSE are considered to be instructive and encouraging, and to see the need for similar programs in the school as well as through the media.