The main goal of this graduate thesis is to determine the extent of abuse of psychoactive substances among high school students in the city of Zagreb, which is stated to be related to factors of individual resistance. The specific aims of the thesis are to explore the existing differences in the frequency of consumption of psychoactive substances in high schools in the city of Zagreb with regard to the presence of individual resistance factors. This research was conducted in the period from October to November 2017 in Zagreb, within the framework of the scientific project "Positive development of adolescents in Zagreb: analysis of the situation". The research covered a representative population of high school students from 25 schools in the Zagreb area. This graduate thesis is based on a specific sample from a large-scale research to data, data collected in four high schools in Zagreb. The schools included in this sample of 719 participants are: III. Gymnasium (N=295), Vladimir Prelog High School (N=176), Geodetic School (N=137) and Carpentry School (N=111). The survey was conducted groupwise and the participation was voluntary and anonymous. Along with demographic variables, individual resilience and protective factors are investigated with scale Resilience and Youth Development Module from California Healthy Kids Survey (Hanson et al., 2007). This approach is based not only on human development studies, but also on the research of school success, healthy families, competent communities, and successful youth programs. Youth development is a process of promoting social, emotional, physical, moral, cognitive and spiritual development through satisfying their basic needs for security, love, affiliation, respect, identity and power. Resistance refers to the positive development of young people in terms of vulnerability, stress and risk. In general, this is not just the ability to recover from the disadvantage, but also the ability to achieve healthy development and successful learning in all circumstances. The main principle of access to young people is that the resilience of healthy development is born to all people. As such, youth development is an essential part of any comprehensive prevention program. Six internal concepts of resistance or individual traits associated with positive development have been taken into account: goals and aspirations, empathy, sense of self-efficacy, cooperation and communication, problem-solving skills and self-awareness. Consumption of psychoactive substances is examined through two questionnaires, of which one first examines the prevalence of consumption and the other consumption of psychoactive substances in the last 30 days. For the purpose of testing the consumption of psychoactive substances, a nine-particle questionnaire that is related to the consumption of alcohol, marijuana, LSD or other psychedelic agents, cocaine or crack, ecstasy, glue or other inhalation agents such as gases or sprays, amphetamine (speed) which are not prescribed by the physician and the last part where it is possible to indicate another non-offered psychoactive substance. For the purpose of this graduate thesis, the relationship between marijuana and individual protective factors, ie factors of individual resistance, is analyzed. The results of the research show that six of the predominant predictors of marijuana abuse during life are only two protective factors, namely weight and problem solving, and that subjects with highly protective factors use marijuana. Other sub-scales of protective factors are not predictors of abuse of marijuana.