Research objectives: To examine the quality of life of people with mental disorders according to groups of disorders, to examine the difference in quality of life of people with mental disorders regarding demographic data and the duration of the disorder, to examine whether there is a difference in the quality of life of the mentally ill, depending on whether they smoke or not and how many cigarettes a day they smoke and whether there is a difference in quality of life of the mentally ill with regard to body mass index (BMI), to examine which are the most significant predictors of the quality of life of psychiatric patients. Respondents and methods: The study was conducted at the Special Hospital for Psychiatry and Palliative Care “Sveti Rafael” in Strmac. 106 respondents participated in the study. A demographic data questionnaire and World Health Organization Quality of Life (WHOQOLBREF) questionnaire were used in the research. Results: Respondents expressed the highest quality of life with the subscale of the environment and the lowest quality of life with the level of independence and physical health. Respondents who are single have better mental health; feel significantly better in the environment and their overall quality of life is higher. Respondents living in the countryside have significantly better physical health as opposed to respondents living in the city. Respondents who consume tobacco products have a significantly better quality of social relationships. Respondents with normal body weight have a significantly better quality of life while obese respondents have a significantly poorer quality of life.Individuals with alcoholism have significantly better physical and mental health. Respondents treated for schizophrenia have a poorer level of independence. Conclusion: Significant negative predictor of the quality of life of psychiatric patients is body mass index.