prikaz prve stranice dokumenta Convergence in Amino Acid Outsourcing Between Animals and Predatory Bacteria
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Convergence in Amino Acid Outsourcing Between Animals and Predatory Bacteria
International Journal of Molecular Sciences, 26 (2025), 7; 1-15. https://doi.org/10.3390/ijms26073024
Kasalo, Niko; Domazet-Lošo, Mirjana; Domazet-Lošo, Tomislav

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Institucijski repozitorij: Repozitorij FER-a

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Kasalo, N., Domazet Lošo, M. i Domazet Lošo, T. (2025). Convergence in Amino Acid Outsourcing Between Animals and Predatory Bacteria. International Journal of Molecular Sciences, 26. (7), 1-15. doi: 10.3390/ijms26073024

Kasalo, Niko, et al. "Convergence in Amino Acid Outsourcing Between Animals and Predatory Bacteria." International Journal of Molecular Sciences, vol. 26, br. 7, 2025, str. 1-15. https://doi.org/10.3390/ijms26073024

Kasalo, Niko, Mirjana Domazet Lošo i Tomislav Domazet Lošo. "Convergence in Amino Acid Outsourcing Between Animals and Predatory Bacteria." International Journal of Molecular Sciences 26, br. 7 (2025): 1-15. https://doi.org/10.3390/ijms26073024

Kasalo, N., Domazet Lošo, M. i Domazet Lošo, T. (2025) 'Convergence in Amino Acid Outsourcing Between Animals and Predatory Bacteria', International Journal of Molecular Sciences, 26(7), str. 1-15. doi: 10.3390/ijms26073024

Kasalo N, Domazet Lošo M, Domazet Lošo T. Convergence in Amino Acid Outsourcing Between Animals and Predatory Bacteria. International Journal of Molecular Sciences [Internet]. 26.03.2025. [pristupljeno 09.04.2025.];26(7):1-15. doi: 10.3390/ijms26073024

N. Kasalo, M. Domazet Lošo i T. Domazet Lošo, "Convergence in Amino Acid Outsourcing Between Animals and Predatory Bacteria", International Journal of Molecular Sciences, vol. 26, br. 7, str. 1-15, Ožujak 2025. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:168:293143. [Citirano: 09.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:168:293143
Podaci o radu
Naslov (engleski)Convergence in Amino Acid Outsourcing Between Animals and Predatory Bacteria
AutorNiko Kasalo
AutorMirjana Domazet-Lošo
AutorTomislav Domazet-Lošo
Autorova ustanovaHrvatsko katoličko sveučilište
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanovaSveučilište u Zagrebu
Fakultet elektrotehnike i računarstva
(Zavod za primijenjeno računarstvo)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Znanstveno / umjetničko
područje, polje i grana		TEHNIČKE ZNANOSTI
Računarstvo
Sažetak (engleski)
All animals have outsourced about half of the 20 proteinogenic amino acids (AAs). We recently demonstrated that the loss of biosynthetic pathways for these outsourced AAs is driven by energy-saving selection. Paradoxically, these metabolic simplifications enabled animals to use costly AAs more frequently in their proteomes, allowing them to explore sequence space more freely. Based on these findings, we proposed that environmental AA availability and cellular respiration mode are the two... Više primary factors determining the evolution of AA auxotrophies in animals. Remarkably, our recent analysis showed that bacterial AA auxotrophies are also governed by energy-related selection, thereby roughly converging with animals. However, bacterial AA auxotrophies are highly heterogeneous and scattered across the bacterial phylogeny, making direct ecological and physiological comparisons with the animal AA outsourcing model challenging. To better test the universality of our model, we focused on Bdellovibrionota and Myxococcota—two closely related bacterial phyla that, through aerobic respiration and a predatory lifestyle, best parallel animals. Here, we show that Bdellovibrionota, driven by energy-related selection, outsourced a highly similar set of AAs to those in animals. This sharply contrasts with Myxococcota, which exhibit far fewer AA auxotrophies and rarely show signatures of energy-driven selection. These differences are also reflected in Bdellovibrionota proteomes, which are substantially more expensive than those of Myxococcota. Finally, we found evidence that the expression of costly proteins plays a crucial role in the predatory phase of the Bdellovibrio life cycle. Together, our findings suggest that Bdellovibrionota, through their obligate predatory lifestyle, exhibit the closest analogy to the AA auxotrophy phenotype observed in animals. In contrast, facultative predation, as seen in Myxococcota, appears to substantially limit the evolution of AA auxotrophies. These cross-domain convergences strongly support the general validity of our AA outsourcing model. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 26, br. 7, str. 1-15, 3024
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms26073024
URN:NBNurn:nbn:hr:168:293143
Datum objave publikacije2025-03-26
ProjektŠifra: KK.01.1.1.01.009
Naziv (hrvatski): DATACROSS - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima
Naziv (engleski): Advanced methods and technologies in Data Science and Cooperative Systems
Kratica: DATACROSS
Voditelj: Sven Lončarić
Pravna nadležnost: eu
Financijer: Europska unija
Linija financiranja: Cohesion Fund
URL dokumentahttps://www.mdpi.com/1422-0067/26/7/3024
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-04-01 10:52:14
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