The topic of this paper is a review of semantic changes that have occurred in Croatian vocabulary. Words from Old Slavonic language which are part of contemporary Croatian lexic but have different meanings were analyzed. The paper is divided into three basic parts. The first part is theoretical, and a brief overview of the lexical semantics development is shown. Furthermore, a few different classifications of the semantic changes are presented. The second part of the paper consists of a table of lexemes with their definitions from Mali staroslavensko-hrvatski rječnik by Stjepan Damjanović, Ivan Jurčević, Tanja Kuštović, Boris Kuzmić, Milica Lukić, and Mateo Žagar. Additionally, definitions are also taken from Veliki rječnik hrvatskog jezika by Vladimir Anić. Along with the meanings of lexemes from Old Slavonic and Croatian languages, the observed semantic changes defined in the first part of the paper are also listed. The analysis of examples from the table is shown in the third part of the paper, along with the comparison of the meaning of currently relevant Croatian lexemes with the meaning of Old Slavonic equivalents. The third part also includes the synthesis of semantic changes along with the brief description of prototype examples.