Research in the field of humor has not been taken seriously for a long time, but in the last twenty years there has been a significant increase in interest and a change in perspective related to humor. Experts deal with issues about how humor can make it easier to cope with stress, improve social relationships or reduce the symptoms of an illness. Today, humor is used as an adjunct to conventional treatment with the goal of helping clients cope with symptoms, improving rehabilitation through emotional, cognitive, social, and physiological impact, and strengthening and facilitating therapy and empowering clients. It is also used as a stand-alone intervention through humor training and humor and laughter therapies. But little research has been done on whether humor interventions affect one’s happiness and life satisfaction. One of the greatest research challenges is methodology. Humor and subjective quality of life are multidimensional constructs and there is currently no consensus among experts about measurement and research approaches. Therefore, this paper presents relevant research on the relationship between humor and subjective quality of life and humor interventions used in different settings. The effect of such interventions on life satisfaction and happiness in different samples of participants are assessed and recommendations for further clinical work are identified. Humor has a great potential in the application and the results of effective intervention on life satisfaction and happiness are promising. In addition, humor positively affects several other variables that are significant to one’s subjective quality of life, giving additional importance to its application in a clinical and health setting.