Lateralization indicates the dominant use of one side of the body over the other and results in right-handedness or left-handedness. About 90% of the human population dominantly uses the right hand, while about 10% uses the left. Researching brain development and genetic factors are trying to explain that disproportion. However, recent studies highlight the great influence of cultural factors. To be specific, throughout the long human history, there was the continuous negative symbolism related to the dominant use of the left hand and the stigmatization of left-handed people. Left-handedness was considered distorted, originating from evil and even a pathological condition. However, contemporary research has shown that it has nothing to do with the onset of disease and that in the last 50 years the number of left-handed people in Europe has increased, which is attributed to the culture of acceptance of left-handedness. Based on that, the goal of this paper is to highlight the possible causes of the low distribution of left-handedness in society. Continuing research of this topic could help normalize left-handedness in society, as well as address the problem of impractical everyday life that left-handed people face sometimes.